Evidence map›Paper›PMID 38126006›Full record

ArticleInfection and drug resistance2023

Drug-Resistant TB, HIV and COVID-19 Co-Infection: Case Reviews from Kwa-Zulu Natal, South Africa.

Razia Hassan-Moosa, Kegaugetswe Wilhemina Motsomi, Radhamoney Narasimmulu, Aida Sivro, Kevindra K Naidu, Ayesha B M Kharsany, Natasha Samsunder, Rubeshan Perumal, Kogieleum Naidoo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Infection and drug resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Razia Hassan-MoosaCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.ORCID 0000-0001-8231-7076
Kegaugetswe Wilhemina MotsomiCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Radhamoney NarasimmuluCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Aida SivroCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Kevindra K NaiduCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Ayesha B M KharsanyCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.ORCID 0000-0001-7457-0194
Natasha SamsunderCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Rubeshan PerumalCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Kogieleum NaidooCentre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.ORCID 0000-0002-8874-6661
Centre for the AIDS Programme of Research in South Africa · ZAPublic Health Agency of Canada · CA

Funding

Medical Research Council MC_PC_16022
6 · The paper itself

Abstract

Background: Coronavirus disease (COVID-19) potentially exacerbates drug-resistant tuberculosis (DR-TB). We describe the clinical presentation and outcomes of three patients with human immunodeficiency virus (HIV), DR-TB and COVID-19. Case One: A virologically suppressed 31-year-old man on antiretroviral therapy (ART) and multidrug-resistant (MDR)-TB treatment presented with mild COVID-19 and was hospitalised for 10 days of clinical monitoring, despite being clinically stable with normal baseline inflammatory markers. Severe acute respiratory syndrome coronavirus polymerase chain reaction (SARS-CoV-2 PCR) positivity persisted at Day 28. Case Two: A virologically suppressed 37-year-old woman on ART and MDR-TB treatment presented with moderate COVID-19. Baseline inflammatory markers were raised, and dexamethasone and azithromycin were initiated with good clinical improvement. SARS-CoV-2 PCR positivity persisted at Day 28. Case Three: A viraemic 24-year-old woman on second-line ART and MDR-TB treatment, presented with mild COVID-19 disease, normal oxygenation and normal inflammatory markers, and remained clinically stable with negative SARS-CoV-2 PCR at Days 14 and 28. Conclusion: Screening for SARS-CoV-2 infection is advised for DR-TB patients with new or worsening respiratory symptoms.

Indexed as

case reviewsCOVID-19DR-TBHIVscreeningtransmission

Identifiers

PMID38126006
PMCPMC10731725
OpenAlexW4389795292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.