Evidence map›Paper›PMID 38125962›Full record

ArticleEClinicalMedicine2024

Treatment of patent ductus arteriosus and short-term outcomes among extremely preterm infants: a multicentre cohort study.

Aimin Qian, Siyuan Jiang, Xinyue Gu, Shujuan Li, Xiaoping Lei, Wei Shi, Jianguo Zhou, Liyuan Hu, Tiantian Xiao, Yanping Zhu and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Aimin QianDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Siyuan JiangDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Xinyue GuNHC Key Laboratory of Neonatal Diseases, Fudan University, Children's Hospital of Fudan University, Shanghai, China.
Shujuan LiDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Xiaoping LeiDivision of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Wei ShiNeonatal Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jianguo ZhouDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Liyuan HuDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Tiantian XiaoDepartment of Neonatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Yanping ZhuDepartment of Neonatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Yun CaoDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Lizhong DuNeonatal Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wenhao ZhouDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Shoo K LeeMaternal-Infant Care Research Center and Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Rui ChengDepartment of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Rong YinDepartment of Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNChildren's Hospital of Zhejiang University · CNSecond Affiliated Hospital of Nanjing Medical University · CNAffiliated Hospital of Southwest Medical University · CNChengdu Women's and Children's Central Hospital · CNFirst Affiliated Hospital of Xinjiang Medical University · CNMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The optimal treatment strategy for patent ductus arteriosus (PDA) in extremely preterm infants is currently highly controversial. This study aimed to evaluate the association between PDA treatment and short-term outcomes among extremely preterm infants. Methods: This cohort study included all extremely preterm infants (≤27 and 6/7 weeks) who were admitted to hospitals participating in the Chinese Neonatal Network from January 2019 to December 2021, and were diagnosed to have PDA by echocardiogram. PDA treatment was defined as medical treatment and/or surgical ligation of PDA during hospitalization. Short-term outcomes included death, bronchopulmonary dysplasia (BPD), death/BPD, retinopathy of prematurity, necrotizing enterocolitis, and severe brain injury. Multivariate logistic regression was used to evaluate the association between PDA treatment and outcomes. Subgroup analysis were performed among infants with different respiratory support on 3 and 7 days of life. Findings: A total of 2494 extremely preterm infants with the diagnosis of PDA were enrolled, of which 1299 (52.1%) received PDA treatment. PDA treatment was significantly associated with lower risk of death (adjusted odds ratio, 0.48; 95% confidence interval, 0.38-0.60). The decreased risk of death was accompanied by increased risk of BPD and death/BPD. In subgroup analysis according to respiratory support, PDA treatment was associated with lower risk of death among infants who required invasive ventilation. However, the beneficial effect on death was not significant among infants who did not require invasive ventilation. Interpretation: PDA treatment was associated with reduced mortality in extremely preterm infants, but this beneficial effect was mainly present among infants who required invasive ventilation. Funding: This study was funded by the Shanghai Science and Technology Commission's Scientific and Technological Innovation Action Plan (21Y21900800) and the Canadian Institutes of Health Research (CTP87518).

Indexed as

Extremely preterm infantsPatent ductus arteriosusPreterm infantsTreatment

Identifiers

PMID38125962
PMCPMC10730999
OpenAlexW4389266420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.