Evidence map›Paper›PMID 38125908›Full record

ArticleFrontiers in cellular and infection microbiology2023

Adaptive immune protection of the middle ears differs from that of the respiratory tract.

Kalyan K Dewan, Amanda Caulfield, Yang Su, Colleen J Sedney, Maiya Callender, Jillian Masters, Uriel Blas-Machado, Eric T Harvill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Neonatal CD19Frontiers in immunology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kalyan K Dewan *Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Amanda Caulfield *Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Yang SuDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Colleen J SedneyDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Maiya CallenderDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Jillian MastersDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Uriel Blas-MachadoDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Eric T HarvillDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
University of Georgia · US

Funding

Are acellular vaccines driving the rise of pertactin-deficient Bordetella pertussisR21AI156293 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
Protection against Bordetella pertussis transmission conferred by established and novel vaccinesR21AI159347 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
NIAID NIH HHS R21 AI156293NIAID NIH HHS R21 AI159347
6 · The paper itself

Abstract

The efficacy of the adaptive immune system in the middle ear (ME) is well established, but the mechanisms are not as well defined as those of gastrointestinal or respiratory tracts. While cellular elements of the adaptive response have been detected in the MEs following infections (or intranasal immunizations), their specific contributions to protecting the organ against reinfections are unknown. How immune protection mechanisms of the MEs compares with those in the adjacent and attached upper and lower respiratory airways remains unclear. To address these knowledge gaps, we used an established mouse respiratory infection model that we recently showed also involves ME infections.

Indexed as

Bordetella bronchisepticaBordetella InfectionsOtitis MediaRespiratory Tract InfectionsAnimalsEar, MiddleHumansMiceRespiratory Systemadaptive immunityBordetella bronchisepticanatural modelotitis mediavaccination

Identifiers

PMID38125908
PMCPMC10731285
OpenAlexW4389393056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.