Evidence map›Paper›PMID 38125029›Full record

ArticleiScience2023

Quantitative proteomics and RNA-sequencing of mouse liver endothelial cells identify novel regulators of BMP6 by iron.

Allison L Fisher, Chia-Yu Wang, Yang Xu, Sydney Phillips, Joao A Paulo, Beata Małachowska, Xia Xiao, Wojciech Fendler, Joseph D Mancias, Jodie L Babitt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Metal Ion Signaling in Biomedicine.Chemical reviews · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Allison L FisherNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chia-Yu WangNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yang XuNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sydney PhillipsNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Beata MałachowskaDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.
Xia XiaoNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Wojciech FendlerDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland.
Joseph D ManciasDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jodie L BabittNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dana-Farber Cancer Institute · USHarvard University · USMedical University of Lodz · PL

Funding

TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2M
Regulation of Iron Homeostasis by BMP SignalingR01DK087727 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L · 2010 to 2024
$6.0M
BMP Ligands in Hepcidin RegulationR01DK128068 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L, CHRISTIAN, JAN L · 2021 to 2024
$2.6M
The role of NCOA4-mediated ferritinophagy in iron homeostasis and ferroptosisR01DK124384 · NIDDK · DANA-FARBER CANCER INST · PI MANCIAS, JOSEPH D · 2020 to 2024
$1.8M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
NIDDK NIH HHS R01 DK087727NIDDK NIH HHS R01 DK124384NIDDK NIH HHS R01 DK128068NIDDK NIH HHS T32 DK007540NIGMS NIH HHS R01 GM132129
6 · The paper itself

Abstract

Hepcidin is the master hormone governing systemic iron homeostasis. Iron regulates hepcidin by activating bone morphogenetic protein (BMP)6 expression in liver endothelial cells (LECs), but the mechanisms are incompletely understood. To address this, we performed proteomics and RNA-sequencing on LECs from iron-adequate and iron-loaded mice. Gene set enrichment analysis identified transcription factors activated by high iron, including Nrf-2, which was previously reported to contribute to BMP6 regulation, and c-Jun.

Indexed as

Integrative aspects of cell biologyProteomicsSpecialized functions of cellsTranscriptomics

Identifiers

PMID38125029
PMCPMC10730383
OpenAlexW4388914963

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.