Evidence map›Paper›PMID 38125028›Full record

ArticleiScience2023

Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities.

Ava Hosseini, Gillian M Barlow, Gabriela Leite, Mohamad Rashid, Gonzalo Parodi, Jiajing Wang, Walter Morales, Stacy Weitsman, Ali Rezaie, Mark Pimentel and 1 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Biological and Behavioral Responses ofInternational journal of molecular sciences · 2025
    Article
  3. Diet's impact on gut microbial assemblage in health and disease.The Journal of clinical investigation · 2025
    Review
  4. Review
  5. Review
  6. Impacts of non-nutritive sweeteners on the human microbiome.Immunometabolism (Cobham, Surrey) · 2025
    Review
  7. Dual independent mechanisms underlying gut epithelial remodeling upon sugar substitute consumption.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. Article
  9. Characterization of Vitreous Microbiota Dysbiosis Associated with Proliferative Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ava HosseiniMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gillian M BarlowMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gabriela LeiteMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Mohamad RashidMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gonzalo ParodiMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Jiajing WangMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Walter MoralesMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Stacy WeitsmanMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Ali RezaieMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Mark PimentelMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Ruchi MathurMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies using stool samples suggest that non-sugar sweetener (NSS) consumption affects gut microbiome composition. However, stool does not represent the entire gut. We analyzed the duodenal luminal microbiome in subjects consuming non-aspartame non-sugar sweeteners (NANS, N = 35), aspartame only (ASP, N = 9), and controls (CON, N = 55) and the stool microbiome in a subset (N = 40). Duodenal alpha diversity was decreased in NANS vs. CON. Duodenal relative abundance (RA) of

Indexed as

Health sciencesMicrobiome

Identifiers

PMID38125028
PMCPMC10730370
OpenAlexW4388943022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.