Evidence map›Paper›PMID 38125015›Full record

ArticleiScience2023

Simulated spaceflight-induced cardiac remodeling is modulated by gut microbial-derived trimethylamine N-oxide.

Zizhong Liu, Gui Luo, Ruikai Du, Guanghan Kan, Xuan Han, Guohui Zhong, Wenjuan Xing, Ying Cui, Weijia Sun, Jianwei Li and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Zizhong LiuNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Gui LuoDepartment of Rheumatology and Immunology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
Ruikai DuNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Guanghan KanNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Xuan HanNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Guohui ZhongNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Wenjuan XingSchool of Aerospace Medicine, Key Laboratory of Aerospace Medicine of the Ministry of Education, Fourth Military Medical University, Xi'an, China.
Ying CuiSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Weijia SunNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Jianwei LiNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Yuheng LiNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Dingsheng ZhaoNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Xinxin YuanNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Xiaoyan JinNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Yanping HanState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Huiyuan SunBeijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.
Shukuan LingOujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China.
Yingxian LiNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
China Astronaut Research and Training Center · CNBeijing University of Chinese Medicine · CNAir Force Medical University · CNChinese PLA General Hospital · CNInstitute of Microbiology · CNZhejiang Lab · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spaceflight is physically demanding and can negatively affect astronauts' health. It has been shown that the human gut microbiota and cardiac function are affected by spaceflight and simulated spaceflight. This study investigated the effects of the gut microbiota on simulated spaceflight-induced cardiac remodeling using 10° of head-down bed rest (HDBR) in rhesus macaques and 30° of hindlimb unloading (HU) in mice. The gut microbiota, fecal metabolites, and cardiac remodeling were markedly affected by HDBR in macaques and HU in mice, cardiac remodeling in control mice was affected by the gut microbiota of HU mice and that of HU mice was protected by the gut microbiota of control mice, and there was a correlation between cardiac remodeling and the gut microbial-derived metabolite trimethylamine N-oxide. These findings suggest that spaceflight can affect cardiac remodeling by modulating the gut microbiota and fecal metabolites.

Indexed as

Cell biologyMetabolomicsMicrobial geneticsMicrobial metabolismMicrogravity sciencesModel organism

Identifiers

PMID38125015
PMCPMC10730869
OpenAlexW4388915049

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.