ArticleThe Plant cell2024
Interplay of EXO70 and MLO proteins modulates trichome cell wall composition and susceptibility to powdery mildew.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Endogenous RALF peptide function is required for powdery mildew host colonization.The New phytologist · 2026Article
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- A symbiotic MLO gene regulates root development via RALF34-triggered Ca2+ signaling in Lotus japonicus.Plant physiology · 2026Article
- Baiting blast fungi: an engineered NLR domain improves effector recognition.The Plant cell · 2026Article
- The role of MLO in powdery mildew susceptibility depends on a combination of functional specialization and subcellular localization.Plant physiology · 2026Article
- Visual marker-assisted gene editing ofaBIOTECH · 2026Article
- Genome-wide association studies of a pea germplasm reveal novel markers and candidate genes implicated in resistance to Fusarium oxysporum f. sp. pisi races 1 and 2.The plant genome · 2026Article
- Entanglement of plant immunity and endomembrane trafficking revealed by plant-powdery mildew fungal interactions.The New phytologist · 2026Review
- Molecular insights into the production of extracellular vesicles by plants.Plant physiology · 2026Article
- Identification of candidate genes involved in root gall formation during early infection ofFrontiers in plant science · 2026Article
- A major QTL region associated with powdery mildew resistance in leaves and fruits of the reconstructed garden strawberry.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Living off the fat of the plant: Powdery mildew fungi thrive on host thylakoid lipids.The Plant cell · 2025Article
- A powdery mildew core effector protein targets the host endosome tethering complexes HOPS and CORVET in barley.Plant physiology · 2025Article
- Comprehensive comparative assessment of the Arabidopsis thaliana MLO2-CALMODULIN2 interaction by various in vitro and in vivo protein-protein interaction assays.The Biochemical journal · 2023Article
- Comprehensive comparative assessment of thebioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
Exocyst component of 70-kDa (EXO70) proteins are constituents of the exocyst complex implicated in vesicle tethering during exocytosis. MILDEW RESISTANCE LOCUS O (MLO) proteins are plant-specific calcium channels and some MLO isoforms enable fungal powdery mildew pathogenesis. We here detected an unexpected phenotypic overlap of Arabidopsis thaliana exo70H4 and mlo2 mlo6 mlo12 triple mutant plants regarding the biogenesis of leaf trichome secondary cell walls. Biochemical and Fourier transform infrared spectroscopic analyses corroborated deficiencies in the composition of trichome cell walls in these mutants. Transgenic lines expressing fluorophore-tagged EXO70H4 and MLO exhibited extensive colocalization of these proteins. Furthermore, mCherry-EXO70H4 mislocalized in trichomes of the mlo triple mutant and, vice versa, MLO6-GFP mislocalized in trichomes of the exo70H4 mutant. Expression of GFP-marked PMR4 callose synthase, a known cargo of EXO70H4-dependent exocytosis, revealed reduced cell wall delivery of GFP-PMR4 in trichomes of mlo triple mutant plants. In vivo protein-protein interaction assays in plant and yeast cells uncovered isoform-preferential interactions between EXO70.2 subfamily members and MLO proteins. Finally, exo70H4 and mlo6 mutants, when combined, showed synergistically enhanced resistance to powdery mildew attack. Taken together, our data point to an isoform-specific interplay of EXO70 and MLO proteins in the modulation of trichome cell wall biogenesis and powdery mildew susceptibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.