Evidence map›Paper›PMID 38124205›Full record

ArticleTrials2023

Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants.

Chen Chen, Yapeng Lin, Feifeng Liu, Xiaoying Chen, Laurent Billot, Qiang Li, Yiija Guo, Hueiming Liu, Lei Si, Menglu Ouyang and 15 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03790800 (Intensive Ambulance-delivered Blood Pressure Reduction in Hyper-Acute Stroke Trial), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03790800 phase3completednot on this map

Intensive Ambulance-delivered Blood Pressure Reduction in Hyper-Acute Stroke Trial

TypeinterventionalSponsorThe George Institute for Global Health, ChinaRan2020 to 2023Enrolled2,425ConditionsStroke, Acute, Cerebrovascular DisordersArmsurapidil
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 7 countries.

Chen ChenDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, 1800, Yuntai Road, Shanghai, 200120, China.
Yapeng LinDepartment of Neurology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Feifeng LiuDepartment of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, 1800, Yuntai Road, Shanghai, 200120, China.
Xiaoying ChenThe George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Laurent BillotThe George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Qiang LiThe George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Yiija GuoBeijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
Hueiming LiuThe George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Lei SiSchool of Health Sciences, Western Sydney University, Campbelltown, Australia.
Menglu OuyangThe George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Chunfang ZhangShanghai Pudong New Area Medical Emergency Centre, Shanghai, China.
Hisatomi ArimaThe George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Philip M BathStroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Gary A FordOxford University Hospitals NHS Foundation Trust and University of Oxford, Oxford, UK.
Thompson RobinsonCollege of Life Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Else Charlotte SandsetDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Jeffrey L SaverUniversity of California, Los Angeles, USA.
Nikola SpriggStroke Trials Unit, Mental Health & Clinical Neuroscience, University of Nottingham, Nottingham, UK.
H Bart van der WorpDepartment of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, the Netherlands.
Gang LiuClinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Lili Song *The George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia.
Jie Yang *Department of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32# W. Sec 2, 1st Ring Road, Chengdu, China.
Gang Li *Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, 1800, Yuntai Road, Shanghai, 200120, China. ligang@tongji.edu.cn.
Craig S Anderson *The George Institute for Global Health, Faculty of Medicine, UNSW, PO Box M201, Missenden Rd., Sydney, NSW, 2050, Australia. canderson@georgeinstitute.org.au.ORCID http://orcid.org/0000-0002-7248-4863
INTERACT4 Investigators
The George Institute for Global Health · AUUniversity of Nottingham · GBCamden and Campbelltown Hospitals · AUCapital Medical University · CNChengdu Medical College · CNFirst Affiliated Hospital of Chengdu Medical College · CNFukuoka University · JPOslo University Hospital · NOPudong New Area People's Hospital · CNShanghai East Hospital · CNTongji University · CNUniversity Medical Center Utrecht · NLUniversity of California, Los Angeles · USUniversity of Electronic Science and Technology of China · CNUniversity of Leicester · GBUniversity of Oxford · GB

Funding

Clinical Plateau Discipline Construction Project of Shanghai Pudong New Area Health Committee PWYgy2021-05Construction Project of Key Discipline Groups of Shanghai Pudong Health Bureau PWZxq2017-08National Health and Medical Research Council (NHMRC) of Australia APP1149987Pilot Program of East Hospital 2017Shanghai Key Clinical Discipline shslczdzk06103the funding of Sichuan Science and Technology Program 2021YFS0376the International Cooperation Project of Chengdu Science and Technology Bureau 2020-GH02-00057-HZ
6 · The paper itself

Abstract

BACKGROUND AND

aimsUncertainty persists over the effects of blood pressure (BP) lowering in acute stroke. The INTEnsive ambulance-delivered blood pressure Reduction in hyper-Acute stroke Trial (INTERACT4) aims to determine efficacy and safety of hyperacute intensive BP lowering in patients with suspected acute stroke. Given concerns over the safety of this treatment in the pre-hospital setting, particularly in relation to patients with intracerebral hemorrhage, we provide an update on progress of the study and profile of participants to date.

methodsINTERACT4 is an ongoing multicentre, ambulance-delivered, randomized, open-label, blinded endpoint trial of pre-hospital BP lowering in patients with suspected acute stroke and elevated BP in China. Patients are randomized via a mobile phone digital system to intensive (target systolic BP [SBP] <140mmHg within 30 min) or guideline-recommended BP management. Primary outcome is an ordinal analysis of the full range of scores on the modified Rankin scale scores at 90 days.

resultsBetween March 2020 and April 2023, 2053 patients (mean age 70 years, female 39%) were recruited with a mean BP 178/98 mmHg in whom 45% have a diagnosis of primary intracerebral hemorrhage upon arrival at hospital. At the time of presentation to hospital, the mean SBP was 160 and 170mmHg in the intensive and control groups (Δ10 mmHg), respectively. The independent data and safety monitoring board has not identified any safety concerns and recommended continuation of the trial. The sample size was reduced from 3116 to 2320 after meetings in August 2022 as the stroke mimic rate was persistently lower than initially estimated (6% vs 30%). The study is expected to be completed in late 2023 and the results announced in May 2024.

conclusionsINTERACT4 is on track to provide reliable evidence of the effectiveness of ambulance-delivered intensive BP lowering in patients with suspected acute stroke.

trial registrationClinicalTrials.gov NCT03790800 ; registered on 2 January 2019. Chinese Trial Registry ChCTR1900020534 , registered on 7 January 2019.

Indexed as

HypertensionHypotensionStrokeAgedAmbulancesAntihypertensive AgentsBlood PressureCerebral HemorrhageFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as TopicTreatment OutcomeAntihypertensive Agents

Identifiers

PMID38124205
PMCPMC10731692
OpenAlexW4390007061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.