Evidence map›Paper›PMID 38124163›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Beyond Average: α-Particle Distribution and Dose Heterogeneity in Bone Metastatic Prostate Cancer.

Nadia Benabdallah, Peng Lu, Diane S Abou, Hanwen Zhang, David Ulmert, Robert F Hobbs, Hiram A Gay, Brian W Simons, Muhammad A Saeed, Buck E Rogers and 9 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nadia BenabdallahMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Peng LuMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Diane S AbouMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Hanwen ZhangMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
David UlmertDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, California.
Robert F HobbsDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, Maryland.
Hiram A GayDepartment of Radiation Oncology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Brian W SimonsCenter for Comparative Medicine, Baylor University, Houston, Texas.
Muhammad A SaeedDepartment of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Buck E RogersDepartment of Radiation Oncology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Abhinav K JhaMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Yuan-Chuan TaiMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Christopher D MaloneMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Joseph E IppolitoMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Jeff MichalskiDepartment of Radiation Oncology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Jack W JenningsMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Brian C BaumannDepartment of Radiation Oncology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Russell K PachynskiDepartment of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Daniel L J ThorekMallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri; thorek.lab@wustl.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Validation and dissemination of novel physical phantoms for quantitative theranostics researchR01EB031962 · NIBIB · WASHINGTON UNIVERSITY · PI JHA, ABHINAV K · 2022 to 2025
$2.4M
The Radium-223 Combination Therapy Space; Improving Response and Clarifying ToxicitiesR01CA240711 · NCI · WASHINGTON UNIVERSITY · PI MICHALSKI, JEFF M., THOREK, DANIEL LYNDON JAFFE · 2020 to 2024
$2.2M
Opening the Therapeutic Window for PSMA-Targeted Molecular RadiotherapyR01CA229893 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2019 to 2024
$1.9M
Kallikrein-Targeted Alpha-Particle Therapy of Late-Stage Prostate CancerR01CA201035 · NCI · WASHINGTON UNIVERSITY · PI THOREK, DANIEL LYNDON JAFFE · 2017 to 2020
$1.4M
Chelation strategies for s-, p-, and f-block radionuclides for targeted alpha therapyR01EB029259 · NIBIB · CORNELL UNIVERSITY · PI WILSON, JUSTIN J · 2020 to 2023
$1.4M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA201035NCI NIH HHS R01 CA229893NCI NIH HHS R01 CA240711NIAMS NIH HHS P30 AR074992NIBIB NIH HHS R01 EB029259NIBIB NIH HHS R01 EB031962
6 · The paper itself

Abstract

α-particle emitters are emerging as a potent modality for disseminated cancer therapy because of their high linear energy transfer and localized absorbed dose profile. Despite great interest and pharmaceutical development, there is scant information on the distribution of these agents at the scale of the α-particle pathlength. We sought to determine the distribution of clinically approved [

Indexed as

Bone NeoplasmsProstatic NeoplasmsAutoradiographyBone and BonesHumansMaleRadiopharmaceuticalsRadiopharmaceuticals223Raautoradiographybiopsydosimetryα-particle

Identifiers

PMID38124163
PMCPMC10858382

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.