Evidence map›Paper›PMID 38124133›Full record

Trial reportSexually transmitted infections2024

Point-of-care testing for sexually transmitted infections and HIV pre-exposure prophylaxis among pregnant women in South Africa, 2021-2022: randomised controlled trial.

Alex de Voux, Dorothy Chiwoniso Nyemba, Miriam Silliman, Nyiko Mashele, Rufaro Mvududu, Landon Myer, Dvora Joseph Davey

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sexually transmitted infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03902418 (Evaluation of Pre-Exposure Prophylaxis), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03902418 completednot on this map

Evaluation of Pre-Exposure Prophylaxis (PrEP) Initiation, Retention, and Adherence in Pregnant and Breastfeeding Women

TypeobservationalSponsorUniversity of California, Los AngelesRan2019 to 2024Enrolled1,195ConditionsHIV-I InfectionArmsemtricitabine/tenofovir
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Alex de VouxDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town Faculty of Health Sciences, Observatory, Western Cape, South Africa alex.devoux@uct.ac.za.
Dorothy Chiwoniso NyembaDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town Faculty of Health Sciences, Observatory, Western Cape, South Africa.
Miriam SillimanDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.
Nyiko MasheleDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town Faculty of Health Sciences, Observatory, Western Cape, South Africa.
Rufaro MvududuDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town Faculty of Health Sciences, Observatory, Western Cape, South Africa.
Landon MyerDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town Faculty of Health Sciences, Observatory, Western Cape, South Africa.
Dvora Joseph DaveyDivision of Epidemiology and Biostatistics, School of Public Health, University of Cape Town Faculty of Health Sciences, Observatory, Western Cape, South Africa.
Faculty of Public Health · GBUniversity of Cape Town · ZAWestern Cape Department of Health · ZAUniversity of California, Los Angeles · US

Funding

Stepped care to optimize PrEP effectiveness in pregnant and postpartum women (SCOPE-PP) in South AfricaR01HD106862 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DVORA Leah JOSEPH DAVEY · 2021 to 2026
$2.7M
Evaluating the PrEP cascade in HIV-negative pregnant and breastfeeding women in South Africa (PrEP-PP)R01MH116771 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH DAVEY, DVORA LEAH, MYER, BENJAMIN LANDON · 2018 to 2022
$2.5M
Evaluation of pre-exposure prophylaxis cascade in pregnant and breastfeeding women in Cape Town, South AfricaK01TW011187 · FIC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH DAVEY, DVORA LEAH · 2018 to 2022
$698k
FIC NIH HHS K01 TW011187NICHD NIH HHS R01 HD106862NIMH NIH HHS R01 MH116771
6 · The paper itself

Abstract

objectivePregnant and postpartum women (PPW) in Southern Africa are at increased risk of acquiring HIV and curable sexually transmitted infections (STIs). Oral pre-exposure prophylaxis (PrEP) is safe and effective to use during pregnancy to reduce HIV acquisition and vertical transmission. Point-of-care (POC) STI testing can identify PPW at risk of HIV and facilitate risk-differentiated and person-centred counselling to improve PrEP initiation, persistence and adherence. We evaluated the impact of POC STI testing compared with STI syndromic management on PrEP outcomes among PPW in Cape Town, South Africa.

methodsThe STI and PrEP in Pregnancy Study enrolled PPW without HIV and ≤34 weeks pregnant at their regular antenatal care visit with follow-up after 1 month. PPW were randomised to receive POC STI testing or STI syndromic management. PPW randomised to POC STI testing self-collected vaginal swabs for

resultsWe enrolled and randomised 268 pregnant women. Twenty-eight per cent of women were diagnosed with ≥1 STI. Overall, 65% of women initiated and 79% persisted on PrEP with no significant differences by randomisation arm. Secondary analysis demonstrated that an STI diagnosis (positive STI test or reporting STI symptoms) was associated with higher PrEP initiation (adjusted relative risk=1.28; 95% CI 1.08 to 1.52), controlling for arm, maternal and gestational age.

conclusionsPOC STI testing was not associated with PrEP initiation or persistence relative to syndromic management. However, improving STI diagnosis by supplementing syndromic management with POC STI testing could improve PrEP initiation among PPW. TRIAL REGISTRATION NUMBER: NCT03902418; Clinical Trials.gov; 1 April 2019.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisSexually Transmitted DiseasesFemaleHumansPoint-of-Care TestingPregnancyPregnant PeopleSouth AfricaCHLAMYDIA TRACHOMATISNEISSERIA GONORRHOEAEPoint-of-Care TestingPre-Exposure ProphylaxisTRICHOMONAS

Identifiers

PMID38124133
PMCPMC11106734
OpenAlexW4389841762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.