Evidence map›Paper›PMID 38124101›Full record

ArticleBMC neuroscience2023

Regulatory effect of bacterial melanin on the isoforms of new superoxide-producing associates from rat tissues in rotenone-induced Parkinson's disease.

Margarita Danielyan, Kristina Nebogova, Ruzan Simonyan, Anichka Hovsepyan, Zubeida Avetisyan, Karen Simonyan, Gegham Simonyan, Vahagn Khachatryan, Kristine Karapetyan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Margarita DanielyanOrbeli Institute of Physiology NAS RA, Yerevan, Armenia. margaritadanielyan76@gmail.com.
Kristina NebogovaOrbeli Institute of Physiology NAS RA, Yerevan, Armenia.
Ruzan SimonyanInstitute of Biochemistry NAS RA, Yerevan, Armenia.
Anichka HovsepyanScientific and Production Center "Armbiotechnology" NAS RA, Yerevan, Armenia.
Zubeida AvetisyanOrbeli Institute of Physiology NAS RA, Yerevan, Armenia.
Karen SimonyanOrbeli Institute of Physiology NAS RA, Yerevan, Armenia.
Gegham SimonyanInstitute of Biochemistry NAS RA, Yerevan, Armenia.
Vahagn KhachatryanOrbeli Institute of Physiology NAS RA, Yerevan, Armenia.
Kristine KarapetyanOrbeli Institute of Physiology NAS RA, Yerevan, Armenia.
L. A. Orbeli Institute of Physiology NAS RA · AMNational Academy of Sciences of Armenia · AM

Funding

Science Committee of RA 21T-1F282
6 · The paper itself

Abstract

According to recent research, selective neuronal vulnerability in Parkinson's disease (PD) results from several phenotypic traits, including calcium-dependent, feed-forward control of mitochondrial respiration leading to elevated reactive oxygen species and cytosolic calcium concentration, an extensive axonal arbor, and a reactive neurotransmitter. Therefore, antioxidant therapy is a promising direction in the treatment of PD. In vitro studies have indicated the survival-promoting activity of bacterial melanin (BM) on midbrain dopaminergic neuron cultures. It has been established that BM has a number of protective and anti-inflammatory properties, so there is a high probability of a protective effect of BM in the early stages of PD. In this study, PD was induced through the unilateral intracerebral administration of rotenone followed by bacterial melanin. Tissues (brain, lungs, and small intestine) from the observed groups underwent isolation and purification to extract isoforms of new thermostable superoxide (О

Indexed as

Parkinson DiseaseSuperoxidesAnimalsAntioxidantsCalciumDopaminergic NeuronsMelaninsNADPRatsRotenoneAntioxidantsCalciumMelaninsNADPRotenoneSuperoxidesAssociatesBacterial melaninBrainParkinson’s diseaseSmall intestineSuperoxides

Identifiers

PMID38124101
PMCPMC10734125
OpenAlexW4389995914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.