Evidence map›Paper›PMID 38124088›Full record

ArticleBMC medicine2023

Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data.

Farid H Mahmud, Antoine B M Clarke, Yesmino Elia, Jacqueline Curtis, Paul Benitez-Aguirre, Fergus J Cameron, Scott T Chiesa, Cheril Clarson, Jennifer J Couper, Maria E Craig and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01581476. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01581476 phase3completed

Randomised, Double Blind, Placebo Controlled Trial of Angiotensin Converting Enzyme Inhibitors and Statins in the Prevention of Long Term Complications in Young People With Type 1 Diabetes

Ran2009Enrolled443Registered outcomes5Posted comparisons0ConditionsType 1 DiabetesArmsACE inhibitor, Combination therapy, Placebo, Statin
PMID 20017932PMID 18349042PMID 22416821PMID 17257274other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 3 countries.

Farid H MahmudDivision of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada. farid.mahmud@sickkids.ca.
Antoine B M ClarkeDivision of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada.
Yesmino EliaDivision of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada.
Jacqueline CurtisDivision of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada.
Paul Benitez-AguirreInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Sydney, Australia.
Fergus J CameronDepartment of Paediatrics, University of Melbourne, Melbourne, Australia.
Scott T ChiesaInstitute of Cardiovascular Science, University College London, London, UK.
Cheril ClarsonLondon Health Sciences Center, London, ON, Canada.
Jennifer J CouperDepartments of Endocrinology and Diabetes and Medical Imaging, Women's and Children's Hospital, Adelaide, Australia.
Maria E CraigInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Sydney, Australia.
R Neil DaltonEvelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Denis DanemanDivision of Endocrinology, Department of Paediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, RM 5446 Black Wing, Toronto, ON, M5G 1X8, Canada.
Elizabeth A DavisTelethon Kids Institute, University of Western Australia, Perth, Australia.
John E DeanfieldInstitute of Cardiovascular Science, University College London, London, UK.
Kim C DonaghueInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, University of Sydney, Sydney, Australia.
Timothy W JonesTelethon Kids Institute, University of Western Australia, Perth, Australia.
Sally M MarshallFaculty of Clinical Medical Sciences, Diabetes Research Group, Translational and Clinical Research Institute, Newcastle University, 4Th Floor William Leech Building, Framlington Place, Newcastle Upon Tyne, UK.
Andrew NeilOxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
M Loredana MarcovecchioDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
University of Toronto · CAThe University of Sydney · AUThe Kids Research Institute Australia · AUUniversity College London · GBGuy's and St Thomas' NHS Foundation Trust · GBLondon Health Sciences Centre · CANewcastle University · GBThe University of Melbourne · AUUniversity of Cambridge · GBUniversity of Oxford · GBWomen's and Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGiven limited data regarding the involvement of disadvantaged groups in paediatric diabetes clinical trials, this study aimed to evaluate the socioeconomic representativeness of participants recruited into a multinational clinical trial in relation to regional and national type 1 diabetes reference populations.

methodsRetrospective, cross-sectional evaluation of a subset of adolescent type 1 diabetes cardiorenal intervention trial (AdDIT) participants from Australia (n = 144), Canada (n = 312) and the UK (n = 173). Validated national measures of deprivation were used: the Index of Relative Socioeconomic Disadvantage (IRSD) 2016 (Australia), the Material Resources (MR) dimension of the Canadian Marginalisation index 2016 (Canada) and the Index of Multiple Deprivation (IMD) 2015 (UK). Representativeness was assessed by comparing the AdDIT cohort's distribution of deprivation quintiles with that of the local paediatric type 1 diabetes population (regional), and the broader type 1 diabetes population for which the trial's intervention was targeted (national).

resultsRecruited study cohorts from each country had higher proportions of participants with higher SES, and significant underrepresentation of lower SES, in relation to their national references. The socioeconomic make-up in Australia mirrored that of the regional population (p = 0.99). For Canada, the 2nd least deprived (p = 0.001) and the most deprived quintiles (p < 0.001) were over- and under-represented relative to the regional reference, while the UK featured higher regional and national SES bias with over-representation and under-representation from the least-deprived and most-deprived quintiles (p < 0.0001).

conclusionsSignificant national differences in trial participation of low SES participants were observed, highlighting limitations in access to clinical research and the importance of reporting sociodemographic representation in diabetes clinical trials.

trial registrationNCT01581476. Registered on 20 April 2012.

Indexed as

Diabetes Mellitus, Type 1AdolescentAustraliaCanadaClinical Trials as TopicCross-Sectional StudiesHumansRetrospective StudiesSocioeconomic FactorsClinical trialDeprivationMarginalizationMulticenter trialsPaediatricSocioeconomic statusType 1 diabetes

Identifiers

PMID38124088
PMCPMC10734126
OpenAlexW4389992443

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.