Evidence map›Paper›PMID 38124018›Full record

ArticleInternational journal of spine surgery2023

Bone Grafting Options for Single-Level TLIF: So Many Options, What Is the Evidence?

Enoch Kim, Matthew Brennan, Pavithra Margabandu, Nicole Oska, Maria Cielito Robles, Anneliese Rademacher, Edvin Telemi, Tarek Mansour, Victor W Chang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of spine surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Enoch Kim *School of Medicine, Wayne State University, Detroit, MI, USA enoch.kim@med.wayne.edu.
Matthew Brennan *School of Medicine, Wayne State University, Detroit, MI, USA.
Pavithra MargabanduSchool of Medicine, Wayne State University, Detroit, MI, USA.
Nicole OskaSchool of Medicine, Wayne State University, Detroit, MI, USA.
Maria Cielito RoblesCollege of Human Medicine, Michigan State University, East Lansing, MI, USA.
Anneliese RademacherDepartment of Neurosurgery, Henry Ford Health Systems, Detroit, MI, USA.
Edvin TelemiDepartment of Neurosurgery, Henry Ford Health Systems, Detroit, MI, USA.
Tarek MansourDepartment of Neurosurgery, Henry Ford Health Systems, Detroit, MI, USA.
Victor W ChangDepartment of Neurosurgery, Henry Ford Health Systems, Detroit, MI, USA.
Henry Ford Health System · USIndiana University School of MedicineWayne State University · USMichigan State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis review seeks to investigate the clinically relevant bone graft materials in single-level transforaminal lumbar interbody fusion (TLIF) procedures as defined by (1) primary outcomes (ie, fusion rates and complication rates) and (2) patient-reported outcomes (ie, visual analog scale [VAS] and Oswestry disability index [ODI]). Because of the advantages in stimulating bone growth, autologous bone grafts such as the iliac crest bone graft (ICBG) have been the gold standard. Numerous alternatives to ICBG have been introduced. Understanding the risks and benefits of bone graft options is vital to optimizing patient care.

methodsA PubMed search was performed for all clinical studies published between January 2008 and March 2023 that referenced the single-level TLIF procedure as well as one of the following grafts: autograft, allograft, bone morphogenetic protein (BMP), demineralized bone matrix, or mesenchymal stem cells (MSCs). Case studies and reports were excluded.

resultsTwenty-eight studies met the inclusion criteria. Studies from the PubMed search demonstrated similarly high fusion rates across nearly all graft materials, the lone exception being MSCs, which showed lower fusion rates. ICBG grafts experienced higher rates of postoperative graft site pain. The BMP graft material had high rates of radiculitis, heterogeneous ossification, and vertebral osteolysis. Patients saw an overall improvement in VAS and ODI scores with all graft materials.

conclusionLocal autografts and ICBG have been the most studied. Fusion rates during single-level TLIF were similar across all graft materials except MSCs. Patient-reported pain levels improved after TLIF surgery regardless of the type of grafts used. While BMP implants have shown promising benefits, they have introduced a new array of complications not normally seen in ICBG implants. The study is limited by the lack of evidence of certain graft materials as well as nonuniformity in metrics evaluating the efficacy of graft materials.

Indexed as

allograftautologousbone graftbone morphogenic proteinceramicmesenchymal stem cellssingle levelspinal fusionsyntheticsTLIF

Identifiers

PMID38124018
PMCPMC10753332
OpenAlexW4389944761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.