Evidence map›Paper›PMID 38123901›Full record

ReviewCerebellum (London, England)2024

Metabolic Determinants of Cerebellar Circuit Formation and Maintenance.

Manuel Gonzalez-Rodriguez, Isaac Marin-Valencia

Abstract readReview
In one paragraph

Review in Cerebellum (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Mental Health Across the Metabolic Spectrum.Biological psychiatry global open science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Manuel Gonzalez-RodriguezThe Abimael Laboratory of Neurometabolism, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Isaac Marin-ValenciaThe Abimael Laboratory of Neurometabolism, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. isaac.marin-valencia@mssm.edu.

Funding

Mechanisms and Therapies for Cerebellar Development Under Defective Mitochondrial MetabolismK08NS110877 · NINDS · ROCKEFELLER UNIVERSITY · PI MARIN-VALENCIA, ISAAC · 2019 to 2023
$999k
Universal Database for Neurometabolic DiseasesR03NS137124 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARIN-VALENCIA, ISAAC · 2024 to 2024
$169k
NINDS NIH HHS K08 NS110877NINDS NIH HHS R03 NS137124
6 · The paper itself

Abstract

Cells configure their metabolism in a synchronized and timely manner to meet their energy demands throughout development and adulthood. Transitions of developmental stages are coupled to metabolic shifts, such that glycolysis is highly active during cell proliferation, whereas oxidative phosphorylation prevails in postmitotic states. In the cerebellum, metabolic transitions are remarkable given its protracted developmental timelines. Such distinctive feature, along with its high neuronal density and metabolic demands, make the cerebellum highly vulnerable to metabolic insults. Despite the expansion of metabolomic approaches to uncover biological mechanisms, little is known about the role of metabolism on cerebellar development and maintenance. To illuminate the intricate connections between metabolism, physiology, and cerebellar disorders, we examined here the impact of metabolism on cerebellar growth, maturation, and adulthood through the lens of inborn errors of metabolism.

Indexed as

CerebellumAnimalsHumansAtaxiaCerebellumInborn errors of metabolismMetabolismNeurodegenerationNeurodevelopment

Identifiers

PMID38123901
PMCPMC12232606

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.