Evidence map›Paper›PMID 38123867›Full record

ArticleThe international journal of cardiovascular imaging2024

Spironolactone improves left atrial function and atrioventricular coupling in patients with resistant hypertension.

Andrew A Girard, Thomas S Denney, Himanshu Gupta, Louis J Dell'Italia, David A Calhoun, Suzanne Oparil, Oleg F Sharifov, Steven G Lloyd

Abstract read
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Andrew A GirardDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Thomas S DenneyDepartment of Electrical and Computer Engineering, Auburn University, Auburn, AL, USA.
Himanshu GuptaValley Health System, Ridgewood, NJ, USA.
Louis J Dell'ItaliaDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
David A CalhounDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Suzanne OparilDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Oleg F SharifovDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 1808 7th Avenue South, BDB 143, Birmingham, AL, 35294, USA. sharifov@uab.edu.
Steven G LloydDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USAuburn University · USValley Health System · US

Funding

The Impact on Diabetes on Left Ventricular RemodelingP50HL077100 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DELL'LTALIA, LOUIS · 2005 to 2009
$16.5M
Left Ventricular Torsional Hysteresis: A Global Parameter for Diastolic FunctionR01HL104018 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUPTA, HIMANSHU · 2010 to 2014
$1.8M
NHLBI NIH HHS P50 HL077100NHLBI NIH HHS R01 HL104018
6 · The paper itself

Abstract

To determine the blood pressure independent effects of spironolactone on left atrial (LA) size and function in patients with resistant hypertension (RHTN). Patients with RHTN (n = 36, mean age 55 ± 7) were prospectively recruited. Spironolactone was initiated at 25 mg/day and increased to 50 mg/day after 4 weeks. Other antihypertensives were withdrawn to maintain constant blood pressure. Cardiac magnetic resonance imaging was performed at baseline and after 6 months of spironolactone treatment and changes in LA functional metrics were assessed. LA size and function parameters were improved (p < 0.05) from baseline to month-6: LA volumes indexed to body surface area (LAVI) were reduced (LAVI

Indexed as

HypertensionSpironolactoneAldosteroneAtrial Function, LeftHeart AtriaHumansMiddle AgedPredictive Value of TestsProspective StudiesAldosteroneSpironolactoneCardiovascular magnetic resonanceLeft atrial functionLeft atrial strainLeft atrial structureLeft atrioventricular coupling indexResistant hypertension

Identifiers

PMID38123867
OpenAlexW4390032751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.