Evidence map›Paper›PMID 38123742›Full record

SynthesisCancer causes & control : CCC2024

Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project.

Minkyo Song, Harindra Jayasekara, Claudio Pelucchi, Charles S Rabkin, Kenneth C Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Linda M Liao, Rossella Bonzi and 21 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer causes & control : CCC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 17 institutions in 10 countries.

Minkyo SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Harindra JayasekaraCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Claudio PelucchiBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Kenneth C JohnsonSchool of Epidemiology and Public Health, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Jinfu HuHarbin Medical University, Harbin, China.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
Monica FerraroniBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Linda M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Rossella BonziBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
David ZaridzeDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, Moscow, Russia.
Dmitry MaximovitchDepartment of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, Moscow, Russia.
Nuria AragonésConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Vicente MartinConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Gemma Castaño-VinyalsConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Marcela GuevaraConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Shoichiro TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Gerson Shigueaki HamadaNikkei Disease Prevention Center, São Paulo, Brazil.
Akihisa HidakaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Eva NegriDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Mary H WardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Rashmi SinhaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Areti LagiouDepartment of Public and Community Health, School of Public Health, University of West Attica, Athens, Greece.
Pagona LagiouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Paolo BoffettaDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Maria Paula CuradoCentro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo, Brazil.
Nuno LunetEPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
Jesus VioqueConsortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Carlo La VecchiaBranch of Medical Statistics, Biometry, and Epidemiology "G. A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
M Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. camargomc@mail.nih.gov.
Division of Cancer Epidemiology and GeneticsUniversity of Milan · ITCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESNational Cancer Institute · USUniversity of Bologna · ITAC Camargo Hospital · BRCancer Council Victoria · AUHarbin Medical University · CNi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTMunicipal Institute for Medical Research · ESNational and Kapodistrian University of Athens · GRNational Institute of Infectious Diseases · JPNavarre Institute of Health Research · ESPiedmont Reference Center for Epidemiology and Cancer Prevention · ITUCLA Health · USUniversity of Ottawa · CAUniversity of West Attica · GR

Funding

Molecular mechanisms of infection-related cancerZIACP010212 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2010 to 2025
$4.6M
Associazione Italiana per la Ricerca sul Cancro 21378Intramural NIH HHS ZIA CP010212
6 · The paper itself

Abstract

backgroundGastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium.

methodsA total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer were estimated by pooling study-specific ORs using random-effects meta-analysis.

resultsA duration of fertility of ≥ 40 years (vs. < 20), was associated with a 25% lower risk of gastric cancer (OR = 0.75; 95% CI: 0.58-0.96). Compared with never use, ever, 5-9 years and ≥ 10 years use of MHT in postmenopausal women, showed ORs of 0.73 (95% CI: 0.58-0.92), 0.53 (95% CI: 0.34-0.84) and 0.71 (95% CI: 0.50-1.00), respectively. The associations were generally similar for anatomical and histologic subtypes.

conclusionOur results support the hypothesis that reproductive factors and MHT use may lower the risk of gastric cancer in women, regardless of anatomical or histologic subtypes. Given the variation in hormones over the lifespan, studies should address their effects in premenopausal and postmenopausal women. Furthermore, mechanistic studies may inform potential biological processes.

Indexed as

Stomach NeoplasmsFemaleHumansIncidenceMalePremenopauseRisk FactorsEstrogensMHTPostmenopausePremenopause

Identifiers

PMID38123742
PMCPMC12052039
OpenAlexW4390014144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.