Evidence map›Paper›PMID 38123729›Full record

ArticleMolecular psychiatry2024

Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control.

Mojtaba Bandarabadi, Sha Li, Lea Aeschlimann, Giulia Colombo, Stamatina Tzanoulinou, Mehdi Tafti, Andrea Becchetti, Benjamin Boutrel, Anne Vassalli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. A Comprehensive 4-layeredCurrent pharmaceutical biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mojtaba Bandarabadi *Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-4608-1374
Sha Li *Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Lea AeschlimannCentre for Psychiatric Neuroscience, Department of Psychiatry, The Lausanne University Hospital, Lausanne, Switzerland.
Giulia ColomboDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.ORCID 0000-0001-7704-7446
Stamatina TzanoulinouDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6066-2810
Mehdi TaftiDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6997-3914
Andrea BecchettiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy.ORCID 0000-0002-9297-0527
Benjamin BoutrelCentre for Psychiatric Neuroscience, Department of Psychiatry, The Lausanne University Hospital, Lausanne, Switzerland.
Anne VassalliDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland. anne.vassalli@unil.ch.ORCID 0000-0002-5314-5620
University of Lausanne · CHUniversity of Milano-Bicocca · IT

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 190605Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 31003A-144282Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 31003A-182613
6 · The paper itself

Abstract

Hypocretin/Orexin (HCRT/OX) and dopamine (DA) are both key effectors of salience processing, reward and stress-related behaviors and motivational states, yet their respective roles and interactions are poorly delineated. We inactivated HCRT-to-DA connectivity by genetic disruption of Hypocretin receptor-1 (Hcrtr1), Hypocretin receptor-2 (Hcrtr2), or both receptors (Hcrtr1&2) in DA neurons and analyzed the consequences on vigilance states, brain oscillations and cognitive performance in freely behaving mice. Unexpectedly, loss of Hcrtr2, but not Hcrtr1 or Hcrtr1&2, induced a dramatic increase in theta (7-11 Hz) electroencephalographic (EEG) activity in both wakefulness and rapid-eye-movement sleep (REMS). DA

Indexed as

CognitionDopaminergic NeuronsElectroencephalographyOrexin ReceptorsWakefulnessAnimalsArousalDopamineMaleMiceMice, Inbred C57BLMice, KnockoutOrexinsRewardSignal TransductionSleep, REMDopamineHcrtr1 protein, mouseOrexin ReceptorsOrexins

Identifiers

PMID38123729
PMCPMC11116111
OpenAlexW4390056779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.