Evidence map›Paper›PMID 38123718›Full record

ArticleNature metabolism2023

Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis.

Lluc Mosteiro, Thi Thu Thao Nguyen, Simona Hankeova, Daniel Alvarez-Sierra, Mike Reichelt, Shannon M Vandriel, Zijuan Lai, Feroza K Choudhury, Dewakar Sangaraju, Binita M Kamath and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Summary of the Year in Review Lectures at the 2024 Annual Meeting of the American Thyroid Association.Thyroid : official journal of the American Thyroid Association · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Lluc MosteiroDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA. mosteirl@gene.com.ORCID 0000-0003-4041-9706
Thi Thu Thao NguyenDepartment of Oncology Bioinformatics, Genentech, South San Francisco, CA, USA.
Simona HankeovaDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA.ORCID 0000-0002-7797-3818
Daniel Alvarez-SierraTranslational Immunology Group, Vall d'Hebron Institut de Recerca (VHIR), Campus Vall Hebron, Barcelona, Spain.ORCID 0000-0001-8221-5117
Mike ReicheltDepartment of Research Pathology, Genentech, South San Francisco, CA, USA.
Shannon M VandrielDivision of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Zijuan LaiDepartment of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, USA.
Feroza K ChoudhuryDepartment of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, USA.
Dewakar SangarajuDepartment of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA, USA.
Binita M KamathDivision of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Alexis ScherlDepartment of Research Pathology, Genentech, South San Francisco, CA, USA.ORCID 0000-0001-6130-3118
Ricardo Pujol-BorrellTranslational Immunology Group, Vall d'Hebron Institut de Recerca (VHIR), Campus Vall Hebron, Barcelona, Spain.
Robert PiskolDepartment of Oncology Bioinformatics, Genentech, South San Francisco, CA, USA.ORCID 0000-0001-8942-9943
Christian W SiebelDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA. cwsiebel@gmail.com.ORCID 0000-0003-4333-3756
University of Toronto · CADiscovery Communications (United States) · USGene Therapy Laboratory · FRHebron University · PSUniversitat Autònoma de Barcelona · ES

Funding

Genentech (Genentech, Inc.) NA
6 · The paper itself

Abstract

The thyroid functions as an apex endocrine organ that controls growth, differentiation and metabolism

Indexed as

HypothyroidismThyroid Epithelial CellsAdultAnimalsChildHomeostasisHumansMammalsMice

Identifiers

PMID38123718
OpenAlexW4390013208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.