ArticleNature2024
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Activator mimicry by PP6 regulatory subunits directs Aurora A dephosphorylation in mitosis.The EMBO journal · 2026Article
- Template-driven scaffolding of SCFNature · 2026Article
- FAM122A inhibition of PP2A-B55 through a bipartite binding mechanism.bioRxiv : the preprint server for biology · 2026Article
- Molecular requirements for PLK1 activation by T-loop phosphorylation.The EMBO journal · 2026Article
- Protein phosphatase 2A subunit B55 alpha is required for angiotensin type 2 receptor elicited natriuresis.American journal of physiology. Renal physiology · 2026Article
- Protein phosphatase 2A (PP2A) function in male germ cells and its importance for male fertility.Endocrine connections · 2025Review
- Houge-Janssens syndrome.European journal of human genetics : EJHG · 2025Review
- Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment.Nature structural & molecular biology · 2025Article
- Fuzziness in enzymatic catalysis.Current opinion in structural biology · 2025Review
- Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale.Cell reports methods · 2025Article
- The Fascinating Intricacy of pSer/Thr-Specific Phosphatases and Their Higher-Order Complexes: Emerging Concepts.Biochemistry · 2025Review
- AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry.bioRxiv : the preprint server for biology · 2025Article
- Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5.Cell chemical biology · 2025Article
- Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity.Current opinion in structural biology · 2025Review
- Toward universal models for collective interactions in biomolecular condensates.Biophysics reviews · 2025Article
- Article
- Fuzzy protein-DNA interactions and beyond: A common theme in transcription?Current opinion in structural biology · 2024Review
- PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions.Nature communications · 2024Article
- A protein phosphatase 1 specificProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Substrate recognition principles for the PP2A-B55 protein phosphatase.Science advances · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Sathish K R PadiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, USA.
Margaret R VosDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA.
Rachel J GodekDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA.
James R FullerHelix Biostructures, Indianapolis, IN, USA.ORCID 0000-0002-9029-0923
Thomas KruseThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Jamin B HeinThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Jakob NilssonThe Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-4100-1125
Matthew S KelkerHelix Biostructures, Indianapolis, IN, USA.ORCID 0000-0001-8908-2767
Rebecca PageDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT, USA. rpage@uchc.edu.ORCID 0000-0002-4645-1232
Wolfgang PetiDepartment of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, USA. peti@uchc.edu.ORCID 0000-0002-8830-6594
UConn Health · USUniversity of Copenhagen · DKHelix Biomedix (United States) · US
Funding
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MNCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MSerine/Threonine Phosphatases in Neurological DiseasesR01NS124666 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Wolfgang Peti · 2023 to 2026
$2.0MProtein Phosphatase 1 Holoenzyme FormationR01GM144483 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI PETI, WOLFGANG · 2022 to 2025
$1.7MThe regulation of phosphoprotein phosphatases in the nucleusR01GM144379 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Rebecca Page · 2023 to 2026
$1.5MNIGMS NIH HHS R01 GM144379NIGMS NIH HHS R01 GM144483NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129547NINDS NIH HHS R01 NS124666Novo Nordisk Foundation Center for Protein Research i
Abstract
Progression through the cell cycle is controlled by regulated and abrupt changes in phosphorylation
Indexed as
Cryoelectron MicroscopyIntracellular Signaling Peptides and ProteinsIntrinsically Disordered ProteinsPhosphoproteinsProtein Phosphatase 2HumansMitosisNuclear Magnetic Resonance, BiomolecularPhosphorylationcyclic AMP-regulated phosphoprotein 19Intracellular Signaling Peptides and ProteinsIntrinsically Disordered ProteinsPABIR1 protein, humanPhosphoproteinsProtein Phosphatase 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.