Evidence map›Paper›PMID 38123640›Full record

ArticleNature genetics2024

Accurate detection of identity-by-descent segments in human ancient DNA.

Harald Ringbauer, Yilei Huang, Ali Akbari, Swapan Mallick, Iñigo Olalde, Nick Patterson, David Reich

Abstract read
In one paragraph

Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

  1. Article
  2. A refined phylochronology of the second plague pandemic in Western Eurasia.Proceedings of the National Academy of Sciences of the United States of America · 2026
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Harald Ringbauer *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. harald_ringbauer@eva.mpg.de.ORCID 0000-0002-4884-9682
Yilei Huang *Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
Ali AkbariDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Swapan MallickDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Iñigo OlaldeDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-2660-6807
Nick PattersonDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
David ReichDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. reich@genetics.med.harvard.edu.ORCID 0000-0002-7037-5292

Funding

Solving ascertainment bias in ancient DNA using Ultima Genomics sequencingR01HG012287 · NHGRI · HARVARD MEDICAL SCHOOL · PI REICH, DAVID E · 2021 to 2025
$2.7M
NHGRI NIH HHS R01 HG012287
6 · The paper itself

Abstract

Long DNA segments shared between two individuals, known as identity-by-descent (IBD), reveal recent genealogical connections. Here we introduce ancIBD, a method for identifying IBD segments in ancient human DNA (aDNA) using a hidden Markov model and imputed genotype probabilities. We demonstrate that ancIBD accurately identifies IBD segments >8 cM for aDNA data with an average depth of >0.25× for whole-genome sequencing or >1× for 1240k single nucleotide polymorphism capture data. Applying ancIBD to 4,248 ancient Eurasian individuals, we identify relatives up to the sixth degree and genealogical connections between archaeological groups. Notably, we reveal long IBD sharing between Corded Ware and Yamnaya groups, indicating that the Yamnaya herders of the Pontic-Caspian Steppe and the Steppe-related ancestry in various European Corded Ware groups share substantial co-ancestry within only a few hundred years. These results show that detecting IBD segments can generate powerful insights into the growing aDNA record, both on a small scale relevant to life stories and on a large scale relevant to major cultural-historical events.

Indexed as

DNA, AncientGenome, HumanGenotypeHumansPolymorphism, Single NucleotideDNA, Ancient

Identifiers

PMID38123640
PMCPMC10786714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.