Evidence map›Paper›PMID 38123476›Full record

ArticleBMJ open respiratory research2023

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

A Parker Ruhl, Jarrett M Jackson, Carlos J Carhuas, Jessica G Niño de Rivera, Michael P Fay, J Brice Weinberg, Loretta G Que, Hans C Ackerman

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in BMJ open respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

A Parker RuhlLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA parker.ruhl@nih.gov.ORCID 0000-0002-1583-4783
Jarrett M JacksonLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Carlos J CarhuasLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jessica G Niño de RiveraLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Michael P FayBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
J Brice WeinbergDepartment of Medicine and Division of Hematology, Duke University School of Medicine and Durham VA Medical Centers, Durham, North Carolina, USA.
Loretta G QueDepartment of Medicine and Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine and Durham VA Medical Centers, Durham, North Carolina, USA.
Hans C AckermanLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USDuke University · US

Funding

SANDIA: Supplementing L-citrulline to overweight late Asthma oNset phenotypes to increase airway L-arginine/ADMA ratio and Improve Asthma controlR01HL146542 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HOLGUIN, FERNANDO, QUE, LORETTA G · 2019 to 2023
$3.6M
Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese AsthmaR01HL153641 · NHLBI · DUKE UNIVERSITY · PI QUE, LORETTA G · 2020 to 2023
$3.0M
Modulation of Asthma by GSNO-based TherapiesR01HL107590 · NHLBI · DUKE UNIVERSITY · PI FOSTER, MATTHEW WOLF, QUE, LORETTA G · 2013 to 2016
$1.6M
The Role of TLR4 in Environmental AsthmaK23ES011185 · NIEHS · DUKE UNIVERSITY · PI SUNDY, JOHN S · 2001 to 2005
$626k
NHLBI NIH HHS R01 HL107590NHLBI NIH HHS R01 HL146542NHLBI NIH HHS R01 HL153641NIEHS NIH HHS K23 ES011185
6 · The paper itself

Abstract

introductionThe genetic determinants of fractional exhalation of nitric oxide (FeNO), a marker of lung inflammation, are understudied in Black individuals. Alpha globin (

methodsHealthy Black adults were enrolled at four study sites in North Carolina from 2005 to 2008. FeNO was measured in triplicate using a nitric oxide analyzer. The -3.7 kb

results895 individuals were in enrolled in the study and 720 consented for future genetic research; 643 had complete data and were included in this analysis. Median (25th, 75th) FeNO was 20 (13, 31) ppb.

conclusionWe found no association between

Indexed as

Alpha-GlobulinsBlack or African AmericanGene DosageNitric OxideAdultExhalationFemaleFractional Exhaled Nitric Oxide TestingGene DeletionGenotypeHumansMaleYoung AdultAlpha-GlobulinsNitric OxideAirway EpitheliumClinical EpidemiologyExhaled Airway MarkersLung Physiology

Identifiers

PMID38123476
OpenAlexW4390031076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.