ArticleJournal of cachexia, sarcopenia and muscle2024
Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- How well does quantifying 'capillary supply' assess oxygen transport capacity in skeletal muscle?The Journal of physiology · 2026Article
- Muscle fibre denervation in ageing.Clinical science (London, England : 1979) · 2026Review
- Vocal Fold Atrophy in an Alzheimer's Disease Rat Model.The Laryngoscope · 2026Article
- Three-dimensional imaging reveals preserved intrinsic contractile function in aging human skeletal muscle fibers.bioRxiv : the preprint server for biology · 2026Article
- Computational pathology with dynamic convolutional and adaptive kernels.Journal of pathology informatics · 2026Article
- Impact of multiple air pollutants on probable sarcopenia in the UK population: the mediating role of physical activity and biological aging.BMC public health · 2026Article
- Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy.Developmental medicine and child neurology · 2026Review
- PathViT Model for Automated Disease Classification from Skeletal Muscle Histopathology.The American journal of pathology · 2026Article
- Loss of lnc-ORA promotes slow myofiber type formation through suppressing ARIH1-MYH7 interaction.Science China. Life sciences · 2026Article
- Feasibility of neurite oriented diffusion and density imaging in thigh skeletal muscle of volunteers with knee pain: relationship with proton density fat fraction: a cross-sectional study.BMC medical imaging · 2026Article
- Growth performance and muscle histological characteristics of IPB-D3 chickens reared under intensive and free-range systems.Veterinary world · 2026Article
- Morphological differences in myofibre size and shape: A comparative study of the soleus, gastrocnemius, triceps brachii and vastus lateralis in humans and mice.Journal of anatomy · 2026Article
- Computational Pathology with Topological signatures and Visual Word Encoding.Research square · 2025Article
- AFTG-Net: A Deep Attention-based Fusion Framework of Topological and Gradient Features for Pathological Image Analysis.Research square · 2025Article
- Obesity-driven musculotendinous remodeling impairs tissue resilience to mechanical damage.Cell and tissue research · 2025Article
- Ageing leads to selective type II myofibre deterioration and denervation independent of reinnervative capacity in human skeletal muscle.Experimental physiology · 2025Article
- Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia.Nutrients · 2025Review
- Marked irregular myofiber shape is a hallmark of human skeletal muscle ageing and is reversed by heavy resistance training.Journal of cachexia, sarcopenia and muscle · 2024Article
- Factors, mechanisms and improvement methods of muscle strength loss.Frontiers in cell and developmental biology · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAge-related loss of strength is disproportionally greater than the loss of mass, suggesting maladaptations in the neuro-myo-tendinous system. Myofibers are often misshaped in aged and diseased muscle, but systematic analyses of large sample sets are lacking. Our aim was to investigate myofiber shape in relation to age, exercise, myofiber type, species and sex.
methodsVastus lateralis muscle biopsies (n = 265) from 197 males and females, covering an age span of 20-97 years, were examined. The gastrocnemius and soleus muscles of 11 + 22-month-old male C57BL/6 mice were also examined. Immunofluorescence and ATPase stainings of muscle cross-sections were used to measure myofiber cross-sectional area (CSA) and perimeter. From these, a shape factor index (SFI) was calculated in a fibre-type-specific manner (type I/II in humans; type I/IIa/IIx/IIb in mice), with higher values indicating increased deformity. Heavy resistance training (RT) was performed three times per week for 3-4 months by a subgroup (n = 59). Correlation analyses were performed comparing SFI and CSA with age, muscle mass, maximal voluntary contraction (MVC), rate of force development and specific force (MVC/muscle mass).
resultsIn human muscle, SFI was positively correlated with age for both type I (R
conclusionsHere, we identify type I and II myofiber shape in humans as a hallmark of muscle ageing that independently predicts volumetric and functional assessments of muscle health. RT reverts the shape of type II myofibers, suggesting that a lack of myofiber recruitment might lead to myofiber deformity.
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