Evidence map›Paper›PMID 38123153›Full record

ReviewBritish journal of pharmacology2023

The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets.

Stephen P H Alexander, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, O Peter Buneman, Elena Faccenda, Simon D Harding, Michael Spedding and 40 more

Abstract readReview
In one paragraph

Review in British journal of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. The evolving landscape of drug targets.Nature reviews. Drug discovery · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Stephen P H AlexanderSchool of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.ORCID 0000-0003-4417-497X
Eamonn KellySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK.
Alistair A MathieSchool of Allied Health Sciences, University of Suffolk, Ipswich, IP4 1QJ, UK.ORCID 0000-0001-6094-2890
John A PetersNeuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.ORCID 0000-0002-4277-4245
Emma L VealeMedway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK.ORCID 0000-0002-6778-9929
Jane F ArmstrongCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID 0000-0002-0524-0260
O Peter BunemanLaboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, UK.
Elena FaccendaCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID 0000-0001-9855-7103
Simon D HardingCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID 0000-0002-9262-8318
Michael SpeddingSpedding Research Solutions SARL, Le Vésinet, 78110, France.ORCID 0000-0002-1248-8221
John A CidlowskiNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.ORCID 0000-0003-1420-0516
Doriano FabbroPIQUR Therapeutics, Basel, 4057, Switzerland.ORCID 0000-0002-9400-4517
Anthony P DavenportClinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID 0000-0002-2096-3117
Jörg StriessnigPharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020, Innsbruck, Austria.ORCID 0000-0002-9406-7120
Jamie A DaviesCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK.ORCID 0000-0001-6660-4032
Katelin E Ahlers-DannenUniversity of Iowa, Iowa City, USA.
Mohammed AlqinyahUniversity of Georgia, Athens, USA.
Thiruma V ArumugamNational University of Singapore, Singapore, Singapore.
Christopher BodleUniversity of Pittsburgh, Iowa City, USA.
Josephine Buo DagnerUniversity of Georgia, Athens, USA.
Bandana ChakravartiUniversity of Iowa, Iowa City, USA.
Shreoshi P ChoudhuriUniversity of Texas Southwestern Medical Center, Dallas, USA.
Kirk M DrueyNational Institute of Health, Bethesda, USA.
Rory A FisherUniversity of Iowa, Iowa City, USA.
Kyle J GerberTetracore Inc., Athens, USA.
John R HeplerEmory University, Athens, USA.
Shelley B HooksUniversity of Georgia, Athens, USA.
Havish S KanthetiUniversity of Texas Southwestern Medical Center, Dallas, USA.
Behirda KarajUniversity of Michigan, East Lansing, USA.
Somayeh Layeghi-GhalehsoukhtehCobel Darou, Shiraz, Iran.
Jae-Kyung LeeUniversity of Georgia, Athens, USA.
Zili LuoUniversity of Iowa, Iowa City, USA.
Kirill MartemyanovScripps Research Institute, Jupiter, USA.
Luke D MascarenhasUniversity of Texas Southwestern Medical Center, Dallas, USA.
Harrison McNabbPurdue University, West Lafayette, USA.
Carolina Montañez-MirandaEmory University, Athens, USA.
Osita OgujioforUniversity of Texas Southwestern Medical Center, Dallas, USA.
Hoa PhanUniversity of Michigan, East Lansing, USA.
David L RomanUniversity of Iowa, Iowa City, USA.
Vincent ShawMichigan State University, East Lansing, USA.
Benita SjogrenPurdue University, West Lafayette, USA.ORCID 0000-0003-1460-1045
Christopher SobeyLa Trobe University, Clayton, Australia.ORCID 0000-0001-6525-9097
Mackenzie M SpicerUniversity of Iowa, Iowa City, USA.
Katherine E SquiresEmory University, Athens, USA.
Laurie SuttonUniversity of Maryland, Jupiter, USA.
Menbere WendimuUniversity of Georgia, Athens, USA.
Thomas WilkieUniversity of Texas Southwestern Medical Center, Dallas, USA.
Keqiang XieScripps Research Institute, Jupiter, USA.
Qian ZhangPurdue University, West Lafayette, USA.
Yalda ZolghadriUniversity of Texas Southwestern Medical Center, Dallas, USA.

Funding

GLUCOCORTICOID HORMONE ACTIONZ01ES090057 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CIDLOWSKI, JOHN A. · 1996 to 2008
$4.1M
Intramural NIH HHS Z01 ES090057Wellcome Trust
6 · The paper itself

Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

Indexed as

Databases, PharmaceuticalPharmacologyDatabases, FactualHumansIon ChannelsLigandsReceptors, Cytoplasmic and NuclearIon ChannelsLigandsReceptors, Cytoplasmic and Nuclear

Identifiers

PMID38123153
PMCPMC13480408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.