ReviewEuropean neurology2024
Pathophysiology of Contrast-Induced Neurotoxicity: A Narrative Review of Possible Mechanisms.
Review in European neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Efficiency and Optimization of Iodinated Contrast Agents in Cerebral Aneurysm CT Angiography: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Late-Onset Contrast-Induced Encephalopathy After Stent-Assisted Coiling: A Case Report and Review of the Literature.Brain sciences · 2026Article
- Long-segment cervicothoracic spinal cord injury occurring after cerebral angiography: a case report.BMC neurology · 2026Article
- Oxidative Stress-Driven Mechanisms and Biomarkers of Drug-Induced Nephrotoxicity: Translational Insights and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2026Review
- Percutaneous Coronary Intervention Associated With Contrast-Induced Encephalopathy.JACC. Case reports · 2026Article
- Contrast-Induced Encephalopathy After Coronary Angiography With Low-Osmolar Contrast.JACC. Case reports · 2026Article
- Development of 5-Amino-2,4,6-triiodoisophthalic Acid Derivatives for Carbamoylation of Amino Acids.ChemistryOpen · 2025Article
- Machine Learning Model to Predict Iodine Contrast Media-Related Acute Adverse Reaction in Patients Without a Similar History for Enhanced CT.Current medical imaging · 2025Article
- Contrast-Induced Encephalopathy Following Cerebral Angiography: A Case Report and Literature Review.Cureus · 2025Article
- Coronary artery spasms and/or coronary air embolisms and contrast-induced encephalopathy during cryoablation of atrial fibrillation: a case report.European heart journal. Case reports · 2025Article
- Early detection of contrast-induced encephalopathy after mechanical thrombectomy using flat-detector CT: incidence, risk factors, and clinical implications.Neuroradiology · 2025Article
- The Australian Diagnostic Criteria for Contrast-Induced Encephalopathy.Neuroradiology · 2025Article
- Mechanical perfusion in brain banking: methods of assessment and relationship to the postmortem interval.Free neuropathology · 2025Article
- Contrast-induced posterior reversible encephalopathy syndrome following diagnostic angiography of vertebral artery.Surgical neurology international · 2025Article
- Seizures as an Initial Manifestation of Severe Anaphylaxis Following Intrathecal Contrast Injection: A Case Report.Case reports in critical care · 2025Article
- Incidence of contrast-induced neurotoxicity following endovascular treatment of unruptured intracranial aneurysms: a single-centre cohort study.Acta neurologica Belgica · 2024Article
- Contrast-induced encephalopathy following endovascular treatment of intracranial aneurysms.Science progressArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContrast-induced neurotoxicity (CIN) is an increasingly observed event following the administration of iodinated contrast. It presents as a spectrum of neurological symptoms that closely mimic ischaemic stroke, however, CIN remains a poorly understood clinical phenomenon. An appreciation of the underlying pathophysiological mechanisms is essential to improve clinical understanding and enhance decision-making.
methodsA broad literature search of Medline (1946 to December 2022) and Embase (1947 to December 2022) was conducted. Articles discussing the pathophysiology of CIN were reviewed. SUMMARY: The pathogenesis of CIN appears to be multifactorial. A key step is likely blood-brain barrier (BBB) breakdown due to factors including ischaemic stroke, uncontrolled hypertension, and possibly contrast agents themselves, among others. This is followed by passage of contrast agents across the BBB, leading to chemotoxic sequelae on neural tissue. KEY MESSAGES: This review provides a clinically oriented review on the pathophysiology of CIN to enhance knowledge and improve decision-making among clinicians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.