Evidence map›Paper›PMID 38118176›Full record

ArticleJournal of the American Chemical Society2024

Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B.

Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Hermen S Overkleeft, Gideon J Davies, Zachary Armstrong

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yurong ChenLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.
Adrianus M C H van den NieuwendijkLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.
Liang WuYork Structural Biology Laboratory, Department of Chemistry, The University of York, YO10 5DD York, U.K.ORCID 0000-0003-0294-7065
Elisha MoranYork Structural Biology Laboratory, Department of Chemistry, The University of York, YO10 5DD York, U.K.ORCID 0000-0002-3463-6862
Foteini SkoulikopoulouLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.
Vera van RietLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.
Hermen S OverkleeftLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.ORCID 0000-0001-6976-7005
Gideon J DaviesYork Structural Biology Laboratory, Department of Chemistry, The University of York, YO10 5DD York, U.K.ORCID 0000-0002-7343-776X
Zachary ArmstrongLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands.ORCID 0000-0002-4086-2946
Leiden University · NLUniversity of York · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Siastatin B is a potent and effective iminosugar inhibitor of three diverse glycosidase classes, namely, sialidases, β-

Indexed as

Enzyme InhibitorsGlucuronidasePiperidinesGlycoside HydrolasesHeparanaseHumansEnzyme InhibitorsGlucuronidaseGlycoside HydrolasesHeparanasePiperidinessiastatin

Identifiers

PMID38118176
PMCPMC10785800
OpenAlexW4389985109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.