ArticleScience advances2023
An evolutionarily conserved serine protease network mediates melanization and Toll activation in
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Multifunctional lysozymes from the assassin bug Sycanus bifidus: Insecticidal proteins with anticoagulant and melanization inhibition properties.Pest management science · 2026Article
- N-Acetylcysteine Attacks Phenoloxidase to Inhibit Insect Melanization and Boost Fungal Virulence.Journal of fungi (Basel, Switzerland) · 2026Article
- Molting in Pancrustacea Is Characterized by Both Deeply Conserved and Recently Evolved Gene Modules.Genome biology and evolution · 2026Article
- Knockouts of Sulfur Metabolism Genes Induce Chronic Inflammation and Immune Dysregulation inAntioxidants (Basel, Switzerland) · 2026Article
- Proximal labeling of the Golgi secretome reveals fat body-derived humoral factors in Drosophila disc regeneration.The Journal of biological chemistry · 2026Article
- Partial reconstitution of the prophenoloxidase activation system inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Insect immunity unveiled: exploring the molecular and cellular defenses against microbial threats.Archives of microbiology · 2026Review
- Sex bias in iron sequestration by transferrin 1 modulates sexually dimorphic infection outcomes in Drosophila melanogaster.Genetics · 2026Article
- Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chromosome-Scale Atlas ofGenes · 2026Article
- The evolution of the immune system of bees is defined by conservation, expansions, and losses.BMC biology · 2026Article
- Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles.PLoS pathogens · 2026Article
- Life stage-dependent RNA interference in the tropical rock lobsterMarine life science & technology · 2026Article
- Recent insights in the development and functions of insect hemocytes.Current opinion in insect science · 2026Review
- The insect Toll pathway activates antibacterial immunity against the citrus Huanglongbing pathogen.Nature communications · 2026Article
- Discovery of a fungal Tc toxin complex and functional mycoserpin through a novel two-by-two comparative genomics approach.Frontiers in cellular and infection microbiology · 2026Article
- Article
- Disruption ofVirulence · 2025Article
- An updated proteomic analysis ofFly · 2025Article
- A binary-distributed effector modulates fungal host preference for drosophilids by targeting a lineage-specific immune factor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Melanization and Toll pathway activation are essential innate immune mechanisms in insects, which result in the generation of reactive compounds and antimicrobial peptides, respectively, to kill pathogens. These two processes are mediated by phenoloxidase (PO) and Spätzle (Spz) through an extracellular network of serine proteases. While some proteases have been identified in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.