Evidence map›Paper›PMID 38117879›Full record

ArticleScience advances2023

Discovery and verification of extracellular microRNA biomarkers for diagnostic and prognostic assessment of preeclampsia at triage.

Robert Morey, Lara Poling, Srimeenakshi Srinivasan, Carolina Martinez-King, Adanna Anyikam, Kathy Zhang-Rutledge, Cuong To, Abbas Hakim, Marina Mochizuki, Kajal Verma and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Robert MoreyDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8480-4564
Lara PolingDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9145-7254
Srimeenakshi SrinivasanDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Carolina Martinez-KingDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0009-0003-3618-7997
Adanna AnyikamDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Kathy Zhang-RutledgeDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0534-2857
Cuong ToDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Abbas HakimDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-2875-4715
Marina MochizukiDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Kajal VermaDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-9159-9722
Antoinette MasonDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Vy TranDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Morgan MeadsDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-5970-7356
Leah Lamale-SmithDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Hilary RoederDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Mariko HoriiDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-4996-6792
Gladys A RamosDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-9838-4991
Peter DeHoffDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0163-7535
Mana M ParastDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Priyadarshini PanthamDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
Louise C LaurentDepartment of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-2095-7534
University of California San Diego · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
GRADUATE TRAINING PROGRAM IN BIONFORMATICST32GM008806 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, REN, BING · 2001 to 2020
$6.2M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
ExRNAs for Early Identification of Pregnancies at Risk for Placental DysfunctionUH3TR000906 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2015 to 2017
$1.1M
Extracellular Vesicles as a Link Between Placental and Renal Dysfunction in PreeclampsiaR00HD096125 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PANTHAM, PRIYADARSHINI · 2021 to 2023
$747k
NCATS NIH HHS UH3 TR000906NCI NIH HHS P30 CA023100NICHD NIH HHS R00 HD096125NICHD NIH HHS T32 HD007203NIGMS NIH HHS T32 GM008806
6 · The paper itself

Abstract

We report on the identification of extracellular miRNA (ex-miRNA) biomarkers for early diagnosis and prognosis of preeclampsia (PE). Small RNA sequencing of maternal serum prospectively collected from participants undergoing evaluation for suspected PE revealed distinct patterns of ex-miRNA expression among different categories of hypertensive disorders in pregnancy. Applying an iterative machine learning method identified three bivariate miRNA biomarkers (

Indexed as

MicroRNAsPre-EclampsiaBiomarkersFemaleHumansPregnancyPrognosisTriageVascular Endothelial Growth Factor Receptor-1BiomarkersFLT1 protein, humanMicroRNAsMIRN522 microRNA, humanVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID38117879
PMCPMC10732528
OpenAlexW4390021969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.