Evidence map›Paper›PMID 38117876›Full record

ArticleScience advances2023

Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching.

Xueyu Li, Kunpeng Cui, Yong Zheng, Ya Nan Ye, Chengtao Yu, Wenqi Yang, Tasuku Nakajima, Jian Ping Gong

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  8. Interspecies interactions in dual, fibrous gels enable control of gel structure and rheology.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xueyu LiLaboratory of Soft and Wet Matter, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0002-3056-1509
Kunpeng CuiInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo 001-0021, Japan.
Yong ZhengInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0002-9445-1229
Ya Nan YeLaboratory of Soft and Wet Matter, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0001-5023-4487
Chengtao YuLaboratory of Soft and Wet Matter, Division of Soft Matter, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.
Wenqi YangLaboratory of Soft and Wet Matter, Division of Soft Matter, Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan.ORCID 0000-0003-3124-8976
Tasuku NakajimaLaboratory of Soft and Wet Matter, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0002-2235-3478
Jian Ping GongLaboratory of Soft and Wet Matter, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.ORCID 0000-0003-2228-2750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soft materials with mechanical adaptability have substantial potential for various applications in tissue engineering. Gaining a deep understanding of the structural evolution and adaptation dynamics of soft materials subjected to cyclic stretching gives insight into developing mechanically adaptive materials. Here, we investigate the effect of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching training. A polyampholyte hydrogel, composed of hierarchical structures including ionic bonds, transient and permanent polymer networks, and bicontinuous hard/soft-phase networks, is adopted as a model. Conditions for effective training, mild overtraining, and fatal overtraining are demonstrated in soft materials. We further reveal that mesoscale hard/soft-phase networks dominate the long-term memory effect of training and play a crucial role in the asymmetric dynamics of compliance changes and the symmetric dynamics of hydrogel shape evolution. Our findings provide insights into the design of hierarchical structures for adaptive soft materials.

Identifiers

PMID38117876
PMCPMC10732516

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.