ArticleProceedings of the National Academy of Sciences of the United States of America2023
Highly specific σ
Open access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress.Brain sciences · 2026Review
- Eukaryotic initiation factor 3d Regulates Context-Dependent Pain Hypersensitivity Through the Integrated Stress Response.bioRxiv : the preprint server for biology · 2025Article
- GCN2 regulates paclitaxel-induced neuropathic pain.British journal of pharmacology · 2025Article
- Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σJournal of natural products · 2025Article
- Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Long-lasting and fast methylglyoxal-scavenging peptide CycK(Myr)RPain reports · 2025Article
- The mRNA Translation Inhibitor Vioprolide A Prevents Inflammatory Pain-Like Behaviour With Limited Action on Already Established Pain-Like Behaviour in Mice.European journal of pain (London, England) · 2025Article
- Transmembrane Protein 97 (TMEM97): Molecular Target and Treatment in Age-Related Macular Degeneration (AMD).Biomolecules · 2025Review
- Sigma‑2 Receptor/Transmembrane Protein 97 in Pain Modulation: Tracing Historical Roots and Current Research Directions.ACS pharmacology & translational science · 2025Review
- Spatial transcriptomic profiling of human paravertebral sympathetic chain ganglia reveals diabetes-induced neuroplasticity.bioRxiv : the preprint server for biology · 2025Article
- Discovery of Iboga-Derived Ligands for the Sigma‑2 Receptor.ACS bio & med chem Au · 2025Article
- Diroximel Fumarate Acts Through Nrf2 to Attenuate Methylglyoxal-Induced Nociception in Mice and Decrease ISR Activation in DRG Neurons.Diabetes · 2025Article
- Recent Advances in the Development of Sigma Receptor (Radio)Ligands and Their Application in Tumors.ACS pharmacology & translational science · 2025Review
- TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis.Molecular therapy. Nucleic acids · 2025Article
- eEF2K regulates pain through translational control of BDNF.Molecular cell · 2025Article
- Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (Molecules (Basel, Switzerland) · 2025Article
- Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (bioRxiv : the preprint server for biology · 2025Article
- ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans.Pharmacological research · 2024Article
Corrections and comments
- Update of
Authors and funding
17 authors at 3 institutions in 1 country.
Muhammad Saad YousufCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0003-0829-8182
James J SahnNuvoNuro Inc., Austin, TX 78712.
Hongfen YangDepartment of Chemistry, University of Texas at Austin, Austin, TX 78712.
Eric T DavidCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Stephanie ShiersCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0002-9646-1850
Marisol Mancilla MorenoCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Jonathan IketemCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Danielle M RoyerCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Chelsea D GarciaCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Jennifer ZhangCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Veronica M HongCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0002-0359-1198
Subhaan M MianCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0009-0007-0107-5521
Ayesha AhmadCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Benedict J KolberCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.
Daniel J LieblThe Miami Project to Cure Paralysis, Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL 33136.
Stephen F MartinNuvoNuro Inc., Austin, TX 78712.ORCID 0000-0002-4639-0695
Theodore J PriceCenter for Advanced Pain Studies and Department of Neuroscience, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080.ORCID 0000-0002-6971-6221
The University of Texas at Dallas · USThe University of Texas at Austin · USUniversity of Miami · US
Funding
Targeting methylglyoxal-induced diabetic neuropathic pain through the integrated stress responseR01DK134893 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI MUNMUN CHATTOPADHYAY, Muhammad Saad Yousuf · 2023 to 2026
$3.1MPlanning Study for the Development of Sigma 2 ligands as AnalgesicsR61NS127271 · NINDS · UNIVERSITY OF KENTUCKY · PI KOLBER, BENEDICT J, TIDGEWELL, KEVIN JOSEPH · 2023 to 2023
$1.5MDevelopment of positive TMEM97 modulators for treating neuropathic painUG3NS131304 · NINDS · NUVONURO INC · PI MARTIN, STEPHEN · 2023 to 2023
$1.4MBruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529kNIDDK NIH HHS R01 DK134893NIH HHS S10 OD021508NINDS NIH HHS R61 NS127271NINDS NIH HHS UG3 NS131304
Abstract
The sigma 2 receptor (σ
Indexed as
NeuralgiaAnimalsDisease Models, AnimalFemaleGanglia, SpinalHumansLigandsMaleMembrane ProteinsMiceMice, KnockoutNociceptorsSensory Receptor CellsLigandsMembrane ProteinsTMEM97 protein, humandrug discoveryISRpainsigma 2 receptorTMEM97
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.