Evidence map›Paper›PMID 38117448›Full record

ArticleNeurochemical research2024

Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2.

Renata Perlikowska, Joana Silva, Celso Alves, Patricia Susano, Małgorzata Zakłos-Szyda, Agnieszka Skibska, Anna Adamska-Bartłomiejczyk, Karol Wtorek, Jean-Claude do Rego, Jean-Luc do Rego and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Renata PerlikowskaDepartment of Biomolecular Chemistry, Faculty of Medicine, Medical University, Mazowiecka 6/8, 92-215, Lodz, Poland. renata.perlikowska@umed.lodz.pl.
Joana SilvaMARE-Marine and Environmental Sciences Centre, ARNET - Aquatic Research Network, Politécnico de Leiria, 2520-630, Peniche, Portugal.
Celso AlvesMARE-Marine and Environmental Sciences Centre, ARNET - Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614, Peniche, Portugal.
Patricia SusanoMARE-Marine and Environmental Sciences Centre, ARNET - Aquatic Research Network, Politécnico de Leiria, 2520-630, Peniche, Portugal.
Małgorzata Zakłos-SzydaInstitute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 2/22, 90-537, Lodz, Poland.
Agnieszka SkibskaDepartment of Biomolecular Chemistry, Faculty of Medicine, Medical University, Mazowiecka 6/8, 92-215, Lodz, Poland.
Anna Adamska-BartłomiejczykDepartment of Biomolecular Chemistry, Faculty of Medicine, Medical University, Mazowiecka 6/8, 92-215, Lodz, Poland.
Karol WtorekDepartment of Biomolecular Chemistry, Faculty of Medicine, Medical University, Mazowiecka 6/8, 92-215, Lodz, Poland.
Jean-Claude do RegoPlatform of Behavioural Analysis (SCAC), Inserm US51 - CNRS UAR2026 HeRaCLes, Institute For Research and Innovation in Biomedicine (IRIB), University of Rouen Normandy, Rouen, France.
Jean-Luc do RegoPlatform of Behavioural Analysis (SCAC), Inserm US51 - CNRS UAR2026 HeRaCLes, Institute For Research and Innovation in Biomedicine (IRIB), University of Rouen Normandy, Rouen, France.
Alicja KluczykFaculty of Chemistry, University of Wroclaw, 50-383, Wroclaw, Poland.
Rui PedrosaMARE-Marine and Environmental Sciences Centre, ARNET - Aquatic Research Network, ESTM, Politécnico de Leiria, 2520-614, Peniche, Portugal.
Instituto Politécnico de Leiria · PTMedical University of Lodz · PLCentre National de la Recherche Scientifique · FRInstitute for Research and Innovation in Biomedicine · FRLodz University of Technology · PLUniversity of Wrocław · PL

Funding

Associate Laboratory ARNET LA/P/0069/2020CROSS-ATLANTIC PTDC/BIA-OUT/29250/2017Polish National Agency for Academic Exchange BPN/BPT/2021/1/00053Programme for Cooperation in Science between Portugal and Poland through project NEURONS FCT/DRI/PNAAE 2021.09608.CBMthe National Science Center No DEC-2021/05/X/ST5/00294The Portuguese Foundation for Science and Technology (FCT) UIDP/04292/2020 and UIDB/04292/2020
6 · The paper itself

Abstract

Naturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted central effects, such as antinociception, memory consolidation and anxiolytic-like activity. The fact that rubiscolins are potent even when given orally makes them very promising drug candidates. The present work tested whether rubiscolin-6 (R-6, Tyr-Pro-Leu-Asp-Leu-Phe) analogs have neuroprotective and anti-inflammatory effects. These hypotheses were tested in the 6-hydroxydopamine (6-OHDA) injury model of human neuroblastoma SH-SY5Y and lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The determination of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), Caspase-3 activity, lipid peroxidation and nitric oxide (NO) production allowed us to determine the effects of peptides on hallmarks related to Parkinson's Disease (PD) and inflammation. Additionally, we investigated the impact of R-6 analogs on serine-threonine kinase (also known as protein kinase B, AKT) and mammalian target of rapamycin (mTOR) activation. The treatment with analogs 3 (Tyr-Inp-Leu-Asp-Leu-Phe-OH), 5 (Dmt-Inp-Leu-Asp-Leu-Phe-OH) and 7 (Tyr-Inp-Leu-Asp-Leu-Phe-NH

Indexed as

NeuroblastomaNeuroprotective AgentsParkinson DiseasePeptide FragmentsRibulose-Bisphosphate CarboxylaseAnti-Inflammatory AgentsApoptosisCaspase 3Cell Line, TumorHumansInflammationLipopolysaccharidesOxidopaminePeptidesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesAnti-Inflammatory AgentsCaspase 3LipopolysaccharidesNeuroprotective AgentsOxidopaminePeptide FragmentsPeptidesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesRibulose-Bisphosphate Carboxylaserubiscolin 6TOR Serine-Threonine Kinases6-hydroxydopamineAntioxidant activityApoptosisInflammationNatural compoundsNeuroprotectionOxidative stressPeptides

Identifiers

PMID38117448
PMCPMC10901950
OpenAlexW4389993554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.