ArticleEuropean journal of pediatrics2024
Risk factors and prediction models for bronchiolitis obliterans after severe adenoviral pneumonia.
Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Current Trends of Human Adenovirus Types Among Hospitalized Children-A Systematic Review.Viruses · 2025Pooled it
- Clinical characteristics and associated factors of post-infectious bronchiolitis obliterans in children with severe pneumonia and respiratory failure: a retrospective cohort study.BMC pediatrics · 2026Article
- Pathogenesis and Risk Factors of Post-Infectious Bronchiolitis Obliterans in Children: A Focus on Adenovirus and Mycoplasma Infections.Pathogens (Basel, Switzerland) · 2026Review
- Analysis of risk factors for the development of bronchiolitis obliterans in children with severeFrontiers in medicine · 2026Article
- Development and validation of an immune-based nomogram model for predicting severe adenovirus pneumonia in hospitalized children.Frontiers in pediatrics · 2026Article
- Risk factors for bronchiolitis obliterans in children with community-acquired pneumonia and analysis of CT findings and clinical manifestations of pneumonia after the diagnosis of bronchiolitis obliterans.Annals of medicine · 2025Article
- Monitoring human adenovirus loads in bronchoalveolar lavage fluid in non-immunocompromised children with human adenovirus pneumonia.Translational pediatrics · 2025Article
- Risk factors for bronchiolitis obliterans development in children after Mycoplasma pneumoniae pneumonia: a retrospective study of 981 patients.Italian journal of pediatrics · 2025Article
- Development and Validation of a Nomogram for Predicting Bronchiolitis Obliterans in Children with Severe Adenovirus Pneumonia: Identification of Key Risk Factors.Pediatric health, medicine and therapeutics · 2025Article
- Postinfectious Bronchiolitis Obliterans in Children.Canadian respiratory journal · 2025Review
- Comment on: "Drug-associated kidney injury in children: a disproportionality analysis of the FDA adverse event reporting system".European journal of pediatrics · 2024Article
- [Construction of a risk prediction model for bronchiolitis obliterans in children with refractoryZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Severe adenoviral pneumonia (SAP) can cause post-infectious bronchiolitis obliterans (PIBO) in children. We aimed to investigate the relevant risk factors for PIBO and develop a predictive nomogram for PIBO in children with SAP. This prospective study analysed the clinical data of hospitalised children with SAP and categorised them into the PIBO and non-PIBO groups. Least absolute shrinkage and selection operator (LASSO) regressions were applied to variables that exhibited significant intergroup differences. Logistic regression was adopted to analyse the risk factors for PIBO. Additionally, a nomogram was constructed, and its effectiveness was assessed using calibration curves, C-index, and decision curve analysis. A total of 148 hospitalised children with SAP were collected in this study. Among them, 112 achieved favourable recovery, whereas 36 developed PIBO. Multivariable regression after variable selection via LASSO revealed that aged < 1 year (OR, 2.38, 95% CI, 0.82-6.77), admission to PICU (OR, 24.40, 95% CI, 7.16-105.00), long duration of fever (OR, 1.16, 95% CI, 1.04-1.31), and bilateral lung infection (OR, 8.78, 95% CI, 1.32-195.00) were major risk factors for PIBO. The nomogram model included the four risk factors: The C-index of the model was 0.85 (95% CI, 0.71-0.99), and the area under the curve was 0.85 (95% CI, 0.78-0.92). The model showed good calibration with the Hosmer-Lemeshow test (χ
conclusionAge < 1 year, PICU admission, long fever duration, and bilateral lung infection are independent risk factors for PIBO in children with SAP. The nomogram model may aid clinicians in the early diagnosis and intervention of PIBO. WHAT IS KNOWN: • Adenoviruses are the most common pathogens associated with PIBO. • Wheezing, tachypnoea, hypoxemia, and mechanical ventilation are the risk factors for PIBO. WHAT IS NEW: • Age < 1 year, admission to PICU, long duration of fever days, and bilateral lung infection are independent risk factors for PIBO in children with SAP. • A prediction model presented as a nomogram may help clinicians in the early diagnosis and intervention of PIBO.
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