Evidence map›Paper›PMID 38117182›Full record

ArticleThe journal of pathology. Clinical research2024

Dynamic tuft cell expansion during gastric metaplasia and dysplasia.

Bogun Jang, Hyesung Kim, Su-Hyung Lee, Yoonkyung Won, Izumi Kaji, Robert J Coffey, Eunyoung Choi, James R Goldenring

Open access · goldAbstract read
In one paragraph

Article in The journal of pathology. Clinical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Recent advances in spasmolytic polypeptide expressing metaplasia research.World journal of gastrointestinal oncology · 2026
    Review
  5. Review
  6. Review
  7. Short histological kaleidoscope - recent findings in histology. Part IV.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Bogun Jang *Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Hyesung Kim *Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Su-Hyung LeeSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Yoonkyung WonSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Izumi KajiSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5395-0497
Robert J CoffeyEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Eunyoung ChoiSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
James R GoldenringSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-7833-2940
Vanderbilt University · USVanderbilt University Medical Center · USJeju National University Hospital · KR

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Induction and Evolution of Metaplasia in the StomachR01DK101332 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eunyoung Choi, James Richard Goldenring · 2014 to 2026
$5.9M
Hierarchy of oncogenic gene mutations in gastric carcinogenesisR01CA272687 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHOI, EUNYOUNG, GOLDENRING, JAMES RICHARD · 2022 to 2025
$5.3M
Drivers of gastric pre-neoplasiaR37CA244970 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHOI, EUNYOUNG · 2020 to 2025
$2.7M
Ariol SL200 Digital Imaging SystemIS1BX003097 · VA · VETERANS HEALTH ADMINISTRATION · PI GOLDENRING, JAMES RICHARD · 2015 to 2015
–
Oxyntic Atrophy and Novel Gastric Lineages.I01BX000930 · VA · VETERANS HEALTH ADMINISTRATION · PI GOLDENRING, JAMES RICHARD · 2011 to 2025
–
BLRD VA I01 BX000930BLRD VA IS1 BX003097NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA272687NCI NIH HHS R37 CA244970NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 CA272687NIDDK NIH HHS R01 DK101332NIDDK NIH HHS R37 CA244970
6 · The paper itself

Abstract

Tuft cells are chemosensory cells associated with luminal homeostasis, immune response, and tumorigenesis in the gastrointestinal tract. We aimed to elucidate alterations in tuft cell populations during gastric atrophy and tumorigenesis in humans with correlative comparison to relevant mouse models. Tuft cell distribution was determined in human stomachs from organ donors and in gastric pathologies including Ménétrier's disease, Helicobacter pylori gastritis, intestinal metaplasia (IM), and gastric tumors. Tuft cell populations were examined in Lrig1-Kras

Indexed as

Gastritis, HypertrophicStomach NeoplasmsAnimalsCarcinogenesisGastric MucosaHumansHyperplasiaMetaplasiaMiceProto-Oncogene Proteins p21(ras)Transforming Growth Factor alphaTuft CellsProto-Oncogene Proteins p21(ras)Transforming Growth Factor alphagastric atrophygastric cancergastric metaplasiatuft cell

Identifiers

PMID38117182
PMCPMC10766036
OpenAlexW4390013750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.