Evidence map›Paper›PMID 38117060›Full record

ArticlemBio2024

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation.

Matthew H Raymonda, Irene Rodríguez-Sánchez, Xenia L Schafer, Leonid Smorodintsev-Schiller, Isaac S Harris, Joshua Munger

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Glucose-independent human cytomegalovirus replication is supported by metabolites that feed upper glycolytic branches.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew H RaymondaDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Irene Rodríguez-SánchezDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Xenia L SchaferDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Leonid Smorodintsev-SchillerWilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA.
Isaac S HarrisWilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA.
Joshua MungerDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.ORCID 0000-0001-5379-9440
University of Rochester Medical Center · USUniversity of Rochester · US

Funding

Training in Cellular, Biochemical and Molecular SciencesT32GM068411 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2005 to 2019
$3.9M
Metabolic modulation by the HCMV UL38 geneR01AI150698 · NIAID · UNIVERSITY OF ROCHESTER · PI JOSHUA C MUNGER · 2020 to 2026
$2.4M
HCMV-mediated repurposing of AMPK & CaMKK signaling for productive infectionR01AI127370 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2016 to 2020
$1.9M
Zinc Deficiency and Thl Functions: Molecular MechanismsR01AI050698 · NIAID · WAYNE STATE UNIVERSITY · PI PRASAD, ANANDA S · 2002 to 2006
$1.5M
NIAID NIH HHS R01 AI050698NIAID NIH HHS R01 AI127370NIAID NIH HHS R01 AI150698NIGMS NIH HHS T32 GM068411
6 · The paper itself

Abstract

importanceViruses modulate host cell metabolism to support the mass production of viral progeny. For human cytomegalovirus, we find that the viral U

Indexed as

CytomegalovirusCytomegalovirus InfectionsFatty AcidsGlucoseGlycolysisHumansLipogenesisFatty AcidsGlucosefatty acid biosynthesisglycolysishuman cytomegaloviruslipogenesismetabolismTSC2UL38

Identifiers

PMID38117060
PMCPMC10790783
OpenAlexW4389994341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.