ArticleJournal of cachexia, sarcopenia and muscle2024
The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Sarcopenia in cognitive disorders: Toward a shared pathophysiological framework.Osteoporosis and sarcopenia · 2026Review
- Plasma lipids connecting olfaction with cognition and physical function.Scientific reports · 2026Article
- Comparison of the effect of eight weeks of Rhythmic aerobic training and CX-WORX on cholesterol transport and inflammatory factors in obese women.Journal of education and health promotion · 2026Article
- Paraspinal Muscle Fatty Infiltration as a Predictor of Intervertebral Disc Degeneration and Pain Severity in Chronic Low Back Pain.Pain research & management · 2026Article
- Imaging Biomarkers of Cognitive Impairment in Sarcopenia: A Narrative Review.International journal of general medicine · 2026Review
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- Crosstalk Between the Endoplasmic Reticulum and Mitochondria in Skeletal Muscle: Implications for Meat Quality.Animals : an open access journal from MDPI · 2025Review
- Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Metabolomic insight into the link of intermuscular fat with cognitive performance: the Health ABC Study.GeroScience · 2025Article
- Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Bioinformatics and machine learning approaches to explore key biomarkers in muscle aging linked to adipogenesis.BMC musculoskeletal disorders · 2025Article
- Risk factors and predictive modeling in a US population with sarcopenia: a propensity score cohort study.Scientific reports · 2025Article
- Application value of two-dimensional ultrasound and shear-wave elastography parameters in evaluating sarcopenia with essential hypertension.Quantitative imaging in medicine and surgery · 2025Article
- Value of Conventional Ultrasound Combined with Shear Wave Elastography for Sarcopenia in Patients with Cardiovascular Disease.Clinical interventions in aging · 2025Article
- Inflammation and cognitive performance in elite athletes: A cross-sectional study.Brain, behavior, & immunity - health · 2024Article
- Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study.World journal of psychiatry · 2024Article
- Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function.Age and ageing · 2024Article
- The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility.Journal of cachexia, sarcopenia and muscle · 2024Article
- Sarcopenia severity is related to arterial stiffness and hypertension in older Korean population without underweight and obesity: population based cross-sectional study.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMitochondrial dysfunction may contribute to brain and muscle health through inflammation or fat infiltration in the muscle, both of which are associated with cognitive function and mobility. We aimed to examine the association between skeletal muscle mitochondrial function and cognitive and mobility outcomes and tested the mediation effect of inflammation or fat infiltration.
methodsWe analysed data from 596 Baltimore Longitudinal Study of Aging participants who had concurrent data on skeletal muscle oxidative capacity and cognitive and mobility measures of interest (mean age: 66.1, 55% women, 24% Black). Skeletal muscle oxidative capacity was assessed as post-exercise recovery rate (kPCr) via P31 MR spectroscopy. Fat infiltration was measured as intermuscular fat (IMF) via CT scan and was available for 541 participants. Inflammation markers [IL-6, C-reactive protein (CRP), total white blood cell (WBC), neutrophil count, erythrocyte sedimentation rate (ESR), or albumin] were available in 594 participants. We examined the association of kPCr and cognitive and mobility measures using linear regression and tested the mediation effect of IMF or inflammation using the mediation package in R. Models were adjusted for demographics and PCr depletion.
resultskPCr and IMF were both significantly associated with specific cognitive domains (DSST, TMA-A, and pegboard dominant hand performance) and mobility (usual gait speed, HABCPPB, 400 m walk time) (all P < 0.05). IMF significantly mediated the relationship between kPCr and these cognitive and mobility measures (all P < 0.05, proportion mediated 13.1% to 27%). Total WBC, neutrophil count, and ESR, but not IL-6 or CRP, also mediated at least one of the cognitive and mobility outcomes (all P < 0.05, proportion mediated 9.4% to 15.3%).
conclusionsSkeletal muscle mitochondrial function is associated with cognitive performance involving psychomotor speed. Muscle fat infiltration and specific inflammation markers mediate the relationship between muscle mitochondrial function and cognitive and mobility outcomes. Future studies are needed to confirm these associations longitudinally and to understand their mechanistic underpinnings.
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