Evidence map›Paper›PMID 38116577›Full record

ArticleFrontiers in pediatrics2023

Multisystem inflammatory syndrome in children characterized by enhanced antigen-specific T-cell expression of cytokines and its reversal following recovery.

Nathella Pavan Kumar, Kadar M Abbas, Rachel M Renji, Aishwarya Venkataraman, Arul Nancy, Poovazhagi Varadarjan, Elilarasi Selladurai, Thankgavelu Sangaralingam, Ramya Selvam, Akshith Thimmaiah and 6 more

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In one paragraph

Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Nathella Pavan Kumar *Department of Immunology, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Kadar M Abbas *National Institutes of Health-International Center for Excellence in Research, Chennai, India.
Rachel M RenjiNational Institutes of Health-International Center for Excellence in Research, Chennai, India.
Aishwarya VenkataramanDepartment of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Arul NancyNational Institutes of Health-International Center for Excellence in Research, Chennai, India.
Poovazhagi VaradarjanDepartment of Pulmonology, Institute of Child Health and Hospital for Children, Chennai, India.
Elilarasi SelladuraiDepartment of Pulmonology, Institute of Child Health and Hospital for Children, Chennai, India.
Thankgavelu SangaralingamGeneral Pediatrics, Dr. Mehta's Children's Hospital, Chennai, India.
Ramya SelvamGeneral Pediatrics, Dr. Mehta's Children's Hospital, Chennai, India.
Akshith ThimmaiahGeneral Pediatrics, Dr. Mehta's Children's Hospital, Chennai, India.
Suresh NatarajanGeneral Pediatrics, Rainbow Children's Hospital, Chennai, India.
Ganesh RamasamyGeneral Pediatrics, Rainbow Children's Hospital, Chennai, India.
Syed HissarDepartment of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Uma Devi RanganathanDepartment of Immunology, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Subash BabuNational Institutes of Health-International Center for Excellence in Research, Chennai, India.
International Centers for Excellence in Research · INNational Institute of Research in Tuberculosis · INDr. Mehta's Children's Hospital · INInstitute of Child Health · INRainbow Children's Hospital · INNational Institute of Allergy and Infectious Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multisystem inflammatory syndrome (MIS) in children is considered to be a post-infectious complication of COVID-19. T-cell responses in children with this condition have not been well-studied. Methods: We aimed to study the immune responses in children with MIS in comparison to children with acute COVID-19 and children with other infections. Whole blood was stimulated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific antigens and flow cytometry was performed to examine CD4 Results: Children with MIS had higher frequencies of CD4 Conclusion: Our study, therefore, provides evidence of enhanced activation of CD4

Indexed as

CD4+ T cellsCD8+ T cellscellular immune responsesCOVID-19MIS-CSARS-CoV-2

Identifiers

PMID38116577
PMCPMC10728284
OpenAlexW4389345450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.