ReviewResearch and reports in tropical medicine2023
Improving the Treatment of Neonatal Sepsis in Resource-Limited Settings: Gaps and Recommendations.
Review in Research and reports in tropical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Prevalence and bacteriological profile of pathogens causing neonatal sepsis in Tanzania: a systematic review with meta-analysis.BMC pediatrics · 2026Pooled it
- Neonatal Dengue Infection Mimicking Late-Onset Neonatal Sepsis in Endemic Regions: A Case Report Series and a Proposed Diagnostic Framework for Antimicrobial Stewardship.Microorganisms · 2026Article
- Genomic and functional approaches point to potential determinants of neonatalMicrobiology spectrum · 2026Article
- Lactic Acid Bacteria-derived Bacteriocins: A Promising Antimicrobial Strategy against Multidrug-resistant for Neonatal Sepsis Pathogens.Probiotics and antimicrobial proteins · 2026Review
- Article
- Diagnostic utility of serum ferritin in culture proven bacterial infection: an observational study.BMC infectious diseases · 2026Observational
- Maternal and neonatal determinants of newborn sepsis: A case-control study in resource-limited settings.World journal of clinical pediatrics · 2026Article
- "Overview of Global Challenges in Dealing with Neonatal Sepsis and Responsibility of Healthcare Workers": A Narrative Review.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Review
- Early Life Antibiotic Exposure and Intestinal Colonization by Enterobacteriaceae upon Admission to a Neonatal Referral Unit: A Case-Control Study.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Clinical and laboratory parameters associated with bloodstream infections among neonates admitted to a tertiary hospital in Tanzania: a hospital-based cross-sectional study.Frontiers in pediatrics · 2026Article
- Improved mortality in gastroschisis patients after implementation of a standardized management bundle in central Malawi: A single-center follow-up at four years.Journal of pediatric surgery · 2026Article
- Article
- Neonatal fungemia: a case series highlighting the threat posed by non-albicans Candida (NAC) species and a yeast-like filamentous fungus.BMC infectious diseases · 2025Article
- A Rare Familial Case of Harlequin Ichthyosis in an Infant of a Diabetic Mother: A Diagnostic and Management Challenge in Low and Middle Income Settings.Clinical case reports · 2025Article
- Potential Health and Cost Impacts of a Point-of-Care Test for Neonatal Sepsis and Possible Serious Bacterial Infections in Infants: A Modeling Analysis in Two Settings.Open forum infectious diseases · 2025Article
- Global, regional, and national burden of neonatal infectious diseases from 1990 to 2021.Translational pediatrics · 2025Article
- Article
- Clinical prediction models to diagnose neonatal sepsis in low-income and middle-income countries: a scoping review.BMJ global health · 2025Article
- Clinical characteristics, antimicrobial resistance, and mortality of neonatal bloodstream infections in Northern Tanzania, 2022-2023.PloS one · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Neonatal sepsis causes significant global morbidity and mortality, with the highest burden in resource-limited settings where 99% of neonatal deaths occur. There are multiple challenges to achieving successful treatment of neonates in this setting. Firstly, reliable and low-cost strategies for risk identification are urgently needed to facilitate treatment as early as possible. Improved laboratory capacity to allow identification of causative organisms would support antimicrobial stewardship. Antibiotic treatment is still hampered by availability, but also increasingly by antimicrobial resistance - making surveillance of organisms and judicious antibiotic use a priority. Finally, supportive care is key in the management of the neonate with sepsis and has been underrecognized as a priority in resource-limited settings. This includes fluid balance and nutritional support in the acute phase, and follow-up care in order to mitigate complications and optimise long-term outcomes. There is much more work to be done in identifying the holistic needs of neonates and their families to provide effective family-integrated interventions and complete the package of neonatal sepsis management in resource-limited settings.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.