Evidence map›Paper›PMID 38116445›Full record

ArticleACS medicinal chemistry letters2023

Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.

Christopher G Thomson, Kelly Boss, Amy Calhoun, Cary Fridrich, Kevin M Gardinier, Edward C Hall, Keith Jendza, Louise Kirman, Nancy Labbé-Giguere, Kurt Laumen and 13 more

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 3 countries.

Christopher G ThomsonGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Kelly BossGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Amy CalhounGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Cary FridrichGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Kevin M GardinierGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Edward C HallGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Keith JendzaGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Louise KirmanGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.ORCID https://orcid.org/0009-0009-3348-6012
Nancy Labbé-GiguereGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Kurt LaumenGlobal Discovery Chemistry, Novartis Biomedical Research, Basel CH-4002, Switzerland.
Ming QianGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Sanjit SanyalGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Michael D ShultzGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.ORCID https://orcid.org/0000-0001-7920-955X
Radka SnajdrovaGlobal Discovery Chemistry, Novartis Biomedical Research, Basel CH-4002, Switzerland.ORCID https://orcid.org/0000-0002-4809-1066
Kian TanGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.ORCID https://orcid.org/0000-0001-8243-1223
Kate Yaping WangGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Fan YangGlobal Discovery Chemistry, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Feng GaoChemical & Analytical Development, Suzhou, Novartis Technical Development, Co., Ltd., Changshu, Jiangsu 215537, P. R. China.ORCID https://orcid.org/0000-0001-9080-072X
Tao HongChemical & Analytical Development, Suzhou, Novartis Technical Development, Co., Ltd., Changshu, Jiangsu 215537, P. R. China.
Elena DaleNeuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Brent KuzmiskiNeuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Danny OrtunoNeuroscience Disease Area, Novartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Daniel S PalaciosGlobal Discovery Chemistry, Novartis Biomedical Research, San Diego, California 92121, United States.ORCID https://orcid.org/0000-0002-5229-0631
Novartis (United States) · USNovartis (China) · CNNovartis (Switzerland) · CHGenomics Institute of the Novartis Research Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed a chiral route toward the synthesis of muscarinic M4 agonists that was enabled by the biocatalytic synthesis of the key spirocyclic diamine building blocks

Identifiers

PMID38116445
PMCPMC10726473
OpenAlexW4388445070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.