Evidence map›Paper›PMID 38116433›Full record

ArticleACS medicinal chemistry letters2023

Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport.

Krishna Kaku, Manasa P Ravindra, Nian Tong, Shruti Choudhary, Xinxin Li, Jianming Yu, Mohammad Karim, Madelyn Brzezinski, Carrie O'Connor, Zhanjun Hou and 2 more

Open access · hybridAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Krishna KakuDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.ORCID https://orcid.org/0000-0002-3073-8060
Manasa P RavindraDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Nian TongDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Shruti ChoudharyDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Xinxin LiDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Jianming YuDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Mohammad KarimDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Madelyn BrzezinskiDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Carrie O'ConnorDepartment of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, United States.
Zhanjun HouMolecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, Michigan 48201, United States.ORCID https://orcid.org/0000-0001-5631-5202
Larry H MatherlyMolecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, Detroit, Michigan 48201, United States.ORCID https://orcid.org/0000-0001-6860-8133
Aleem GangjeeDivision of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.ORCID https://orcid.org/0000-0002-5513-7616
Duquesne University · USWayne State University · US

Funding

MOLECULAR REGULATION OF FOLATE AND ANTIFOLATE TRANSPORTR01CA053535 · NCI · WAYNE STATE UNIVERSITY · PI HOU, ZHANJUN, MATHERLY, LARRY H · 1993 to 2024
$6.3M
Therapeutic Targeting Mitochondrial C1 MetabolismR01CA250469 · NCI · WAYNE STATE UNIVERSITY · PI DANN, CHARLES E., GANGJEE, ALEEM · 2021 to 2025
$3.0M
NCI NIH HHS R01 CA053535NCI NIH HHS R01 CA250469
6 · The paper itself

Abstract

Pemetrexed and related 5-substituted pyrrolo[2,3-

Identifiers

PMID38116433
PMCPMC10726441
OpenAlexW4388701120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.