Evidence map›Paper›PMID 38116117›Full record

ArticleCell genomics2023

The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders.

Nis Borbye-Lorenzen, Zhihong Zhu, Esben Agerbo, Clara Albiñana, Michael E Benros, Beilei Bian, Anders D Børglum, Cynthia M Bulik, Jean-Christophe Philippe Goldtsche Debost, Jakob Grove and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 5 countries.

Nis Borbye-LorenzenCenter for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Zhihong ZhuNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark. Electronic address: z.zhu.ncrr@au.dk.
Esben AgerboNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Center for Integrated Register-based Research, Aarhus University, CIRRAU, 8210 Aarhus V, Denmark.
Clara AlbiñanaNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark.
Michael E BenrosCopenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital, Hellerup, Denmark; Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Beilei BianInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Anders D BørglumThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Department of Biomedicine and the iSEQ Center, Aarhus University, Aarhus, Denmark; Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jean-Christophe Philippe Goldtsche DebostNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; Department of Psychosis, Aarhus University Hospital Skejby, Aarhus Nord, Denmark.
Jakob GroveThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Center for Genomics and Personalized Medicine, CGPM, Aarhus, Denmark; Department of Biomedicine (Human Genetics), Aarhus University, Aarhus, Denmark; Bioinformatics Research Center, Aarhus University, 8000 Aarhus C, Denmark.
David M HougaardThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Department for Congenital Disorders, Statens Serum Institut, 2300 Copenhagen S, Denmark.
Allan F McRaeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Psychosis Research Unit, Aarhus University Hospital - Psychiatry, Aarhus, Denmark.
Preben Bo MortensenNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Center for Integrated Register-based Research, Aarhus University, CIRRAU, 8210 Aarhus V, Denmark.
Katherine L MuslinerDepartment of Affective Disorders, Aarhus University and Aarhus University Hospital -Psychiatry, Aarhus, Denmark.
Merete NordentoftThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, 2100 Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
Liselotte V PetersenNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark.
Florian PrivéNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark.
Julia SidorenkoInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Kristin SkogstrandCenter for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Thomas WergeThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark; Department of Clinical Medicine, Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, University of Copenhagen, 2200 Copenhagen N, Denmark; Lundbeck Center for Geogenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
Naomi R WrayInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK; Big Data Institute, University of Oxford, Oxford OX3 7LF, UK.
Bjarni J VilhjálmssonNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, 8210 Aarhus V, Denmark; Bioinformatics Research Center, Aarhus University, 8000 Aarhus C, Denmark.
John J McGrathNational Center for Register-Based Research, Aarhus University, 8210 Aarhus V, Denmark; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Brisbane, QLD 4076, Australia. Electronic address: j.mcgrath@uq.edu.au.
Aarhus University · DKThe University of Queensland · AUStatens Serum Institut · DKUniversity of Copenhagen · DKAarhus University Hospital · DKLundbeck Foundation · DKUniversity of North Carolina at Chapel Hill · US

Funding

Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M
2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4M
1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M
Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems ApproachR01MH119084 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, BUTNER, JONATHAN · 2019 to 2022
$2.8M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH124851NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH136149NIMH NIH HHS R56 MH129437
6 · The paper itself

Abstract

Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.

Indexed as

autoimmune disordersC3C4complement componentdried blood spotsgenome-wide association studyMendelian randomizationphenome-wide association studypsychiatric disordersschizophrenia

Identifiers

PMID38116117
PMCPMC10726496
OpenAlexW4389687941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.