Evidence map›Paper›PMID 38116115›Full record

ReviewCell genomics2023

Advancing pathogen genomics in resource-limited settings.

Paul Michael Pronyk, Ruklanthi de Alwis, Rebecca Rockett, Kerri Basile, Yann Felix Boucher, Vincent Pang, October Sessions, Marya Getchell, Tanya Golubchik, Connie Lam and 13 more

Abstract readReview
In one paragraph

Review in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Review
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  6. Article
  7. Review
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  13. Review
  14. Integrating metagenomics and metatranscriptomics intoThe Journal of general virology · 2026
    Review
  15. Advancing genomics for waterborne pathogen surveillance in Australia.The Lancet regional health. Western Pacific · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Genetic Diversity of Methicillin-ResistantInternational journal of microbiology · 2026
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Paul Michael PronykCentre for Outbreak Preparedness, Duke-NUS Medical School, Singapore 169857, Singapore. Electronic address: ppronyk@duke-nus.edu.sg.
Ruklanthi de AlwisCentre for Outbreak Preparedness, Duke-NUS Medical School, Singapore 169857, Singapore; Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore 169857, Singapore.
Rebecca RockettSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, Westmead, NSW 2145, Australia.
Kerri BasileCentre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead, NSW 2145, Australia.
Yann Felix BoucherSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 117549, Singapore; Singapore Centre for Environmental Life Sciences Engineering, National University of Singapore, Singapore 117549, Singapore; Nanyang Technological University, Singapore 639798, Singapore.
Vincent PangCentre for Outbreak Preparedness, Duke-NUS Medical School, Singapore 169857, Singapore.
October SessionsSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia.
Marya GetchellCentre for Outbreak Preparedness, Duke-NUS Medical School, Singapore 169857, Singapore.
Tanya GolubchikSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, Westmead, NSW 2145, Australia; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.
Connie LamSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, Westmead, NSW 2145, Australia.
Raymond LinNational Public Health Laboratory, National Centre for Infectious Diseases, Singapore 308442, Singapore.
Tze-Minn MakBioinformatics Institute, Agency for Science, Technology and Research, Singapore 138671, Singapore.
Ben MaraisSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia.
Rick Twee-Hee OngSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
Hannah Eleanor ClaphamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore.
Linfa WangEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore 169857, Singapore; Programme for Research in Epidemic Preparedness and Response (PREPARE), Ministry of Health, Singapore 169854, Singapore.
Yorin CahyoriniCenter for Health Resilience and Resource Policy, Ministry of Health, Jakarta 12950, Indonesia.
Francisco Gerardo M PolotanMolecular Biology Laboratory, Research Institute for Tropical Medicine, Muntinlupa 1781, Metro Manila, Philippines.
Yuni RukminiatiCenter for Health Resilience and Resource Policy, Ministry of Health, Jakarta 12950, Indonesia.
Eby SimSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, Westmead, NSW 2145, Australia.
Carl SusterSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, Westmead, NSW 2145, Australia.
Gavin J D SmithEmerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore 169857, Singapore.
Vitali SintchenkoSydney Infectious Diseases Institute, The University of Sydney, Camperdown, NSW 2006, Australia; Centre for Infectious Diseases and Microbiology - Public Health, Westmead Hospital, Westmead, NSW 2145, Australia; Centre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead, NSW 2145, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic sequencing has emerged as a powerful tool to enhance early pathogen detection and characterization with implications for public health and clinical decision making. Although widely available in developed countries, the application of pathogen genomics among low-resource, high-disease burden settings remains at an early stage. In these contexts, tailored approaches for integrating pathogen genomics within infectious disease control programs will be essential to optimize cost efficiency and public health impact. We propose a framework for embedding pathogen genomics within national surveillance plans across a spectrum of surveillance and laboratory capacities. We adopt a public health approach to genomics and examine its application to high-priority diseases relevant in resource-limited settings. For each grouping, we assess the value proposition for genomics to inform public health and clinical decision-making, alongside its contribution toward research and development of novel diagnostics, therapeutics, and vaccines.

Indexed as

emerging infectious diseasesgenomicspathogen genomicsresource-limited settingssurveillancewhole-genome sequencing

Identifiers

PMID38116115
PMCPMC10726422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.