ArticleFrontiers in immunology2023
Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptome.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 29 citations in OpenAlex.
- Safety considerations for cereblon-recruiting targeted protein degraders.Nature reviews. Drug discovery · 2026Review
- Single-cell immune landscape of patients with different ovarian reserves during COH.Functional & integrative genomics · 2026Article
- Sleep deprivation impairs follicular development attributable to granulosa cell pyroptosis mediated by S100A8/A9-driven macrophage M1 polarization.Science advances · 2026Article
- Interpreting the molecular and cellular landscape of PCOS through bulk transcriptomics, single-cell transcriptomics and machine learning.Journal of ovarian research · 2026Article
- The importance of ovary-immune interactions in the context of age and disease.Frontiers in neuroendocrinology · 2026Review
- The Impact of Oxidative Stress Imbalance on Ovarian Function and Its Mechanisms.International journal of general medicine · 2026Review
- Dietary oxidative balance and renal impairment in diabetes identified by machine learning and functional analysis.Frontiers in nutrition · 2026Article
- From menses to ovulation: the immunomodulatory role of monocyte cytokines in menstrual cycle physiology and reproductive health - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Identification of ferroptosis- and mitochondrial metabolism-related biomarkers and the potential molecular mechanisms of poor ovarian response.Journal of ovarian research · 2025Article
- Mechanisms and applications of mesenchymal stem cell exosomes in enhancing fertility.Stem cell research & therapy · 2025Review
- Recent advances in reprogramming lactate metabolism in polycystic ovary syndrome.Journal of ovarian research · 2025Review
- Effects of Gossypol Exposure on Ovarian Reserve Function: Comprehensive Risk Assessment Based on TRAEC Strategy.Toxics · 2025Article
- Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure.Cell proliferation · 2025Review
- Noninvasive markers for warning premature ovarian insufficiency: a Mendelian randomisation study.Journal of ovarian research · 2025Article
- Anti-infertility roles of flavonoids: insights into the female reproductive system.Molecular biology reports · 2025Review
- Inverse relationship of oxidative balance score with hyperuricemia among Chinese adults: a population-based cross-sectional study.BMC public health · 2025Observational
- The dual nature of immunotherapy in female reproductive disorders: immune homeostasis and clinical challenges.Frontiers in immunology · 2025Review
- The Association Between Sleep Disorder and Female Infertility: A Mediation Analysis of Inflammatory and Oxidative Markers.Mediators of inflammation · 2025Article
- Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013-2020.Frontiers in nutrition · 2025Article
- PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome.Frontiers in immunology · 2025Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Ovulation dysfunction is now a widespread cause of infertility around the world. Although the impact of immune cells in human reproduction has been widely investigated, systematic understanding of the changes of the immune atlas under female ovulation remain less understood. Methods: Here, we generated single cell transcriptomic profiles of 80,689 PBMCs in three representative statuses of ovulation dysfunction, i.e., polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI) and menopause (MENO), and identified totally 7 major cell types and 25 subsets of cells. Results: Our study revealed distinct cluster distributions of immune cells among individuals of ovulation disorders and health. In patients with ovulation dysfunction, we observed a significant reduction in populations of naïve CD8 T cells and effector memory CD4 T cells, whereas circulating NK cells and regulatory NK cells increased. Discussion: Our results highlight the significant contribution of cDC-mediated signaling pathways to the overall inflammatory response within ovulation disorders. Furthermore, our data demonstrated a significant upregulation of oxidative stress in patients with ovulation disorder. Overall, our study gave a deeper insight into the mechanism of PCOS, POI, and menopause, which may contribute to the better diagnosis and treatments of these ovulatory disorder.
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