Evidence map›Paper›PMID 38116004›Full record

ArticleFrontiers in immunology2023

Monocyte populations are involved in the pathogenesis of experimental epidermolysis bullosa acquisita.

Reza Akbarzadeh, Christianna Czyz, Sarah-Yasmin Thomsen, Paul Schilf, Sripriya Murthy, Christian D Sadik, Peter König

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Reza AkbarzadehDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Christianna CzyzInstitute of Anatomy, University of Lübeck, Lübeck, Germany.
Sarah-Yasmin ThomsenDepartment of Dermatology, Allergy, and Venereology, University of Lübeck, Lübeck, Germany.
Paul SchilfDepartment of Dermatology, Allergy, and Venereology, University of Lübeck, Lübeck, Germany.
Sripriya MurthyDepartment of Dermatology, Allergy, and Venereology, University of Lübeck, Lübeck, Germany.
Christian D SadikDepartment of Dermatology, Allergy, and Venereology, University of Lübeck, Lübeck, Germany.
Peter KönigInstitute of Anatomy, University of Lübeck, Lübeck, Germany.
University of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue populations. Pemphigoid diseases constitute a group of autoimmune blistering skin diseases featuring a marked infiltration of the dermis with immune cells, including monocytes. The monocyte subsets infiltrating the skin, however, have largely remained elusive. Monocyte adhesion and recruitment into the inflamed tissues are regulated by chemokine receptors, most prominently by CCR2 and CX3CR1. To delineate the involvement of monocyte populations in autoimmune blistering skin diseases, we spatiotemporally monitored the dynamic spectrum of monocyte populations that infiltrate the inflamed skin using multiphoton intravital imaging and reporter mice for chemokine receptors. Experimental epidermolysis bullosa acquisita (EBA) was induced by injection of anti-murine type VII collagen (amCOLVII) IgG into the Csf1r

Indexed as

Epidermolysis Bullosa AcquisitaPemphigoid, BullousAnimalsBlisterMiceMonocytesReceptors, ChemokineSkinReceptors, Chemokineautoimmune diseaseCCR2CX3CR1intravital imagingmonocyte

Identifiers

PMID38116004
PMCPMC10728641
OpenAlexW4389344678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.