Evidence map›Paper›PMID 38115102›Full record

ReviewParasites & vectors2023

Genetic diversity of Toxoplasma gondii in South America: occurrence, immunity, and fate of infection.

Ramayana Morais de Medeiros Brito, Gabriella de Lima Bessa, Alexandre Lazoski Bastilho, Filipe Dantas-Torres, Valter Ferreira de Andrade-Neto, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Luisa M D Magalhães

Abstract readReview
In one paragraph

Review in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Evolution ofJournal of parasitology research · 2026
    Review
  7. Article
  8. Article
  9. Sarcocystid pathogens in captive monkeys from southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  10. Article
  11. Global geographical distribution ofParasite epidemiology and control · 2025
    Review
  12. Parasitology · 2025
    Article
  13. Article
  14. Parasitology · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ramayana Morais de Medeiros BritoLaboratory of Immunobiology and Control of Parasites, Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Gabriella de Lima BessaCentro Universitário do Planalto Central Apparecido dos Santos, UNICEPLAC, Brasília, Brazil.
Alexandre Lazoski BastilhoLaboratory of Malaria and Toxoplasmosis Biology, Department of Microbiology and Parasitology, Biosciences Centre, Federal University of Rio Grande do Norte, Natal, Brazil.
Filipe Dantas-TorresAggeu Magalhães Institute, Fundação Oswaldo Cruz (Fiocruz), Recife, Brazil.
Valter Ferreira de Andrade-NetoLaboratory of Malaria and Toxoplasmosis Biology, Department of Microbiology and Parasitology, Biosciences Centre, Federal University of Rio Grande do Norte, Natal, Brazil.
Lilian Lacerda BuenoLaboratory of Immunobiology and Control of Parasites, Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Ricardo Toshio FujiwaraLaboratory of Immunobiology and Control of Parasites, Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil. fujiwara@icb.ufmg.br.
Luisa M D MagalhãesLaboratory of Immunobiology and Control of Parasites, Department of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil. luisamdmagalhaes@gmail.com.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #305514/2022-9Conselho Nacional de Desenvolvimento Científico e Tecnológico #306036/2019-3Conselho Nacional de Desenvolvimento Científico e Tecnológico #312151/2020-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior PhD ScholarshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior Post-doctoral fellowship
6 · The paper itself

Abstract

Toxoplasma gondii is an intracellular parasite with a worldwide distribution. Toxoplasma gondii infections are of great concern for public health, and their impact is usually most severe in pregnant women and their foetuses, and in immunocompromised individuals. Displaying considerable genetic diversity, T. gondii strains differ widely according to geographical location, with archetypal strains predominantly found in the Northern Hemisphere and non-archetypal (atypical) strains, with highly diverse genotypes, found mainly in South America. In this review, we present an overview of the identification and distribution of non-archetypal strains of T. gondii. Special attention is paid to the strains that have been isolated in Brazil, their interaction with the host immunological response, and their impact on disease outcomes. The genetic differences among the strains are pivotal to the distinct immunological responses that they elicit. These differences arise from polymorphisms of key proteins released by the parasite, which represent important virulence factors. Infection with divergent non-archetypal strains can lead to unusual manifestations of the disease, even in immunocompetent individuals.

Indexed as

ToxoplasmaToxoplasmosisToxoplasmosis, AnimalAnimalsBrazilFemaleGenetic VariationGenotypeHumansPolymorphism, GeneticPregnancyAtypical strainsImmunityToxoplasmosisVirulence factors

Identifiers

PMID38115102
PMCPMC10729521

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.