SynthesisJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2023
Early-onset juvenile nasopharyngeal angiofibroma (JNA): a systematic review.
Synthesis in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Extranasopharyngeal angiofibroma of the sinonasal tract: A systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Pooled it
- Article
- Unilateral proptosis as the primary presentation of Stage IVb Juvenile Nasopharyngeal Angiofibroma with direct external carotid artery supply: Case report.Radiology case reports · 2026Article
- Imaging for Pediatric Head and Neck Emergencies: Critical Insights.Journal of the Korean Society of Radiology · 2026Review
- Molecular Mechanisms of Juvenile Nasopharyngeal Angiofibroma: A Narrative Review.Current oncology (Toronto, Ont.) · 2026Review
- The management of extensive juvenile nasopharyngeal angiofibroma involving the carotid artery: An illustrative case series and literature review original.Radiology case reports · 2026Article
- Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024).World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Juvenile nasopharyngeal angiofibroma: analysis of 12 cases and review of the literature.Open medicine (Warsaw, Poland) · 2026Article
- Recurrent Juvenile Nasopharyngeal Angiofibroma: Two Cases Emphasizing the Role of Follow-Up and Staging in Surgical Planning.International medical case reports journal · 2026Article
- Article
- Article
- Gamma Knife Radiosurgery for Advanced and Recurrent Juvenile Nasopharyngeal Angiofibroma: A Case Series.Brain tumor research and treatment · 2025Article
- The radiological perspective of juvenile nasopharyngeal angiofibroma: A case report.Radiology case reports · 2025Article
- Article
- Juvenile Nasopharyngeal Angiofibroma: A Case Study on the Diagnostic and Surgical Challenges in an Adolescent Male.Cureus · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundJuvenile Nasopharyngeal Angiofibroma (JNA) is a fibrovascular tumor of the nasopharynx that classically presents in adolescent males. The reported mean age of onset is between 13 and 22 years old [1-6]. Significant androgen stimulation is hypothesized to explain the strong predisposition for JNA to present in young adolescent males. However, considerable variability in age at diagnosis exists with rare involvement of very young patients incongruent with typical male pubertal growth patterns.
objectiveThe purpose of this systematic review is to identify cases of early-onset JNA (EOJNA), (defined as age < 10 years) in the literature and to examine the disease characteristics and treatments used in this patient group. A case of a 7 year old boy with EOJNA at our institution is also described and presented.
methodsWe searched Embase, Cochrane database and MEDLINE from 1996 to February 2021 for studies that reported cases of EOJNA. Relevant clinico-demographic data, disease severity and treatment outcomes were recorded and analyzed using descriptive statistics. We compared our findings with reported means for JNA in all ages.
resultsWe identified 29 studies containing a total of 34 cases of EOJNA. The vast majority (31/34) of patients were males and the mean age of diagnosis was 8.15 years old. The most common presenting symptoms were nasal obstruction (65.2%) and epistaxis (60.9%). Patients were most commonly Radkowski stage II (39.4%) and III (39.4%). Primary treatment modalities included open surgery (66.7%), endoscopic surgery (24.2%), and radiotherapy (9.1%). Recurrence was evident in 30%. Radkowski stage and type of treatment did not differ significantly within the EOJNA group (p = 0.440 and p = 0.659, respectively).
conclusionThis systematic review suggests that rare cases of EOJNA have distinct disease characteristics. Patients in this cohort appeared to have more advanced disease and higher recurrence rates when compared with reported averages. We hope that this review prompts increased clinical awareness of this potentially more aggressive subtype of JNA. As more cases of EOJNA are reported, a more powered statistical analysis of this cohort would be feasible.
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