ArticleParasites & vectors2023
Toxocara canis-induced changes in host intestinal microbial communities.
Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Winter is coming … How the hoarding behaviour of rodents fosters the persistence ofInternational journal for parasitology. Parasites and wildlife · 2026Article
- Cocktail vaccine induces immunoprotection and modulates the fecal microbiota in dogs against Echinococcus granulosus infection.NPJ vaccines · 2025Article
- Effects of Different Levels of Flea Infestation on Gut Microbiota of Brandt's Voles (Animals : an open access journal from MDPI · 2025Article
- Parasites in Sewage: Legal Requirements and Diagnostic Tools.Pathogens (Basel, Switzerland) · 2025Review
- Effect of Toxocara canis infection on liver and lung microbial flora diversity and composition in dogs.Parasite (Paris, France) · 2025Article
- 16S rDNA-based detection technology: use in lambs infected with Nematodirus oiratianus to analyze changes in intestinal flora.Parasite (Paris, France) · 2025Article
- Impacts of ectoparasite flea infestation on gut microbiota of the Meriones unguiculatus in a rodent-flea system.Parasitology research · 2024Article
- Regulation Effect ofMicroorganisms · 2024Article
- Modulation of the rat intestinal microbiota in the course ofFrontiers in veterinary science · 2024Article
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Authors and funding
5 authors.
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Abstract
backgroundToxocara canis is a roundworm that resides in the gastrointestinal tract of dogs and causes various pathological changes. The dog's intestinal system consists of a diverse and dynamic bacterial community that has extensive effects on intestinal physiology, immunity and metabolics. In the case of intestinal parasites, interactions with the host intestinal flora are inevitable during the process of parasitism.
methodsWe studied the role of T. canis in regulating the composition and diversity of the intestinal flora of the host by high-throughput sequencing of the 16S ribosomal RNA gene and various bioinformatics analyses.
resultsThe α-diversity analysis showed that Toxocara canis infection resulted in a significant decrease in the abundance and diversity of host intestinal flora. The β-diversity analysis showed that the intestinal flora of infected dogs was similar to that carried by T. canis. Analysis of the microflora composition and differences at the phylum level showed that the ratio of Firmicutes to Bacteroidetes (F/B ratio) increased with T. canis infection. Analysis of species composition and differences at the genus level revealed that the proportion of some of the pathogenic bacteria, such as Clostridium sensu stricto and Staphylococcus, increased after T. canis infection.
conclusionsToxocara canis infection affected the composition and diversity of the flora in the host intestinal tract. These results not only shed light on the potential mechanism of T. canis invasion and long-term survival in the intestinal tract, but also provide a new basis for the development of anthelmintic drugs.
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