Evidence map›Paper›PMID 38115011›Full record

ArticleJournal of neuroinflammation2023

TNFR1 signaling converging on FGF14 controls neuronal hyperactivity and sickness behavior in experimental cerebral malaria.

Nolan M Dvorak, Nadia D Domingo, Cynthia M Tapia, Paul A Wadsworth, Mate Marosi, Yosef Avchalumov, Chanida Fongsaran, Leandra Koff, Jessica Di Re, Catherine M Sampson and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. mTORC2-NaChannels (Austin, Tex.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 4 institutions in 1 country.

Nolan M DvorakDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Nadia D DomingoDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Cynthia M TapiaDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Paul A WadsworthDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Mate MarosiDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Yosef AvchalumovDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Chanida FongsaranDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Leandra KoffDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jessica Di ReDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Catherine M SampsonDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Timothy J BaumgartnerDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Pingyuan WangDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Paula P VillarrealDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Olivia D SolomonDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Sonja J StutzCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch, Galveston, TX, 77555, USA.
AditiDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jacob PorterDepartment of Chemistry, University of Texas, Austin, TX, 78712, USA.
Komi GbedandeDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Brendan PrideauxDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Thomas A GreenDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Erin H SeeleyDepartment of Chemistry, University of Texas, Austin, TX, 78712, USA.
Parimal SamirDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Kelley T DineleyCenter for Addiction Sciences and Therapeutics, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Gracie VargasDepartment of Neurobiology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Jia ZhouDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Irma CisnerosDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Robin StephensDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX, 77555, USA. Robin.Stephens@Rutgers.edu.
Fernanda LaezzaDepartment of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, 77555, USA. felaezza@utmb.edu.
The University of Texas Medical Branch at Galveston · USThe University of Texas at Austin · USRutgers New Jersey Medical School · USRutgers, The State University of New Jersey · US

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Probing brain circuit and behavior with protein:protein interaction modulatorsR01MH132226 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Fernanda Laezza, Jia Zhou · 2023 to 2026
$3.2M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Neurotoxicology of deltamethrin in the developing brainR01ES031823 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GREEN, THOMAS ARTHUR, LAEZZA, FERNANDA · 2020 to 2024
$2.8M
Validation of FGF14 as a New Molecular Target of GSK3R01MH095995 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2012 to 2016
$1.9M
Mechanisms of Neuroinflammation in Experimental Cerebal MalariaR01NS106597 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI STEPHENS, ROBIN, VARGAS, GRACIE · 2018 to 2023
$1.9M
Discovery of Chemical Probes for Psychiatric Disorders and AddictionR01MH111107 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, ZHOU, JIA · 2016 to 2018
$1.6M
Predoctoral and Postdoctoral Training in Alzheimer's PathophysiologyT32AG067952 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAYED, RAKEZ · 2021 to 2025
$1.5M
Brain derived extracellular vesicles-mediated neurotoxicity of deltamethrinR21ES034956 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA, PENDYALA, GURUDUTT · 2023 to 2023
$423k
NIA NIH HHS T32 AG067952NIA NIH HHS T32AG067952-01NIEHS NIH HHS R01 ES031823NIEHS NIH HHS R21 ES034956NIGMS NIH HHS T32 GM008280NIGMS NIH HHS T32GM008280NIMH NIH HHS R01 MH095995NIMH NIH HHS R01MH095995NIMH NIH HHS R01 MH111107NIMH NIH HHS R01MH111107NIMH NIH HHS R01 MH124351NIMH NIH HHS R01 MH132226NINDS NIH HHS R01 NS106597NINDS NIH HHS R01NS106597
6 · The paper itself

Abstract

backgroundExcess tumor necrosis factor (TNF) is implicated in the pathogenesis of hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels of fibrin(ogen) in the brain, behavioral changes, and mortality. However, the role of TNF in eCM within the brain parenchyma, particularly directly on neurons, remains underdefined. Here, we investigate electrophysiological consequences of eCM on neuronal excitability and cell signaling mechanisms that contribute to observed phenotypes.

methodsThe split-luciferase complementation assay (LCA) was used to investigate cell signaling mechanisms downstream of tumor necrosis factor receptor 1 (TNFR1) that could contribute to changes in neuronal excitability in eCM. Whole-cell patch-clamp electrophysiology was performed in brain slices from eCM mice to elucidate consequences of infection on CA1 pyramidal neuron excitability and cell signaling mechanisms that contribute to observed phenotypes. Involvement of identified signaling molecules in mediating behavioral changes and sickness behavior observed in eCM were investigated in vivo using genetic silencing.

resultsExploring signaling mechanisms that underlie TNF-induced effects on neuronal excitability, we found that the complex assembly of fibroblast growth factor 14 (FGF14) and the voltage-gated Na

conclusionsFGF14 may represent a therapeutic target for mitigating consequences of TNF-mediated neuroinflammation.

Indexed as

Illness BehaviorMalaria, CerebralAnimalsFibroblast Growth FactorsMiceNAV1.6 Voltage-Gated Sodium ChannelNeuronsReceptors, Tumor Necrosis Factor, Type ISignal TransductionTumor Necrosis Factor Inhibitorsfibroblast growth factor 14Fibroblast Growth FactorsNAV1.6 Voltage-Gated Sodium ChannelReceptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor InhibitorsHippocampusIon channelsNeuroinflammationNeuronal excitabilityPhosphorylationSynaptic plasticityTherapeutic target

Identifiers

PMID38115011
PMCPMC10729485
OpenAlexW4389943202

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.