ArticleBMC cardiovascular disorders2023
Association between cardiopulmonary bypass time and mortality among patients with acute respiratory distress syndrome after cardiac surgery.
Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Different extubation protocols for adult cardiac surgery: a systematic review and pairwise and network meta-analysis.BMC anesthesiology · 2025Pooled it
- Pre- and Immediate Postoperative Prediction Model for Organ Dysfunction or Death Early After Cardiac Surgery: A Post Hoc Analysis of a Multicenter Randomized Trial.Journal of the American Heart Association · 2026Trial
- Ascending aortic versus axillary artery cannulation in Stanford type A aortic dissection repair: a propensity score-weighted cohort study.Journal of thoracic disease · 2026Article
- Early Prone Positioning After Acute Type A Aortic Dissection Surgery for Moderate-to-Severe Acute Respiratory Distress Syndrome Is Safe and Shortens Duration of Mechanical Ventilation.Critical care explorations · 2026Article
- Mitral valve surgery combined with on-pump coronary artery bypass grafting (CABG) versus off-pump or on-pump beating heart CABG: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Early Outcomes After Total Arch Replacement With Frozen Elephant Trunk in Elderly Patients With Acute Type A Aortic Dissection.Aging medicine (Milton (N.S.W)) · 2026Article
- Value of Thromboelastography as a Predictor of Postoperative Acute Respiratory Distress Syndrome in Patients With Acute Type A Aortic Dissection.Reviews in cardiovascular medicine · 2026Article
- Article
- Impact of Operating Room Efficiencies on Patient Outcomes Following Primary Coronary Artery Bypass Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Development and internal validation of a prediction model for hypoxic hepatitis after coronary artery bypass grafting with cardiopulmonary bypass.Frontiers in medicine · 2026Article
- Risk factors and a predictive model for delayed extubation in children undergoing primary repair of tetralogy of Fallot: a retrospective cohort study with rigorous methodological validation.Frontiers in pediatrics · 2026Article
- Management of cardiopulmonary bypass in children with hypoplastic left heart syndrome undergoing multiple sternotomy procedures: a case report.Translational pediatrics · 2025Article
- Short- and Medium-Term Surgical Outcomes of Tissue-Engineered Pulmonary Valve Replacement in Sheep.Tissue engineering and regenerative medicine · 2025Article
- Effect of sevoflurane on hemodynamic response during cardiopulmonary bypass in cardiac surgery patients: A randomized controlled trial.Journal of cardiovascular and thoracic research · 2025Article
- Red Cell Distribution Width as a Predictive Biomarker for Early Lung Injury in Pediatric Patients Following Cardiopulmonary Bypass.Children (Basel, Switzerland) · 2025Article
- Kinesiophobia and associated factors among patients after cardiac surgery under cardiopulmonary bypass: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Machine learning prediction of ARDS after heart valve surgery: development and validation in Northwest China.Frontiers in cardiovascular medicine · 2025Article
- Tree-based ensemble machine learning models in the prediction of acute respiratory distress syndrome following cardiac surgery: a multicenter cohort study.Journal of translational medicine · 2024Observational
- Temperature management in acute type A aortic dissection treatment: deep vs. moderate hypothermic circulatory arrest. Is colder better?Frontiers in cardiovascular medicine · 2024Article
- Heart-lung crosstalk in acute respiratory distress syndrome.Frontiers in physiology · 2024Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was to investigate the impact of CPB time on clinical outcomes in patients with ARDS after cardiac surgery.
methodsTotally, patients with ARDS after cardiac surgery in Beijing Anzhen Hospital from January 2005 to December 2015 were retrospectively included and were further divided into three groups according to the median time of CPB. The primary endpoints were the ICU mortality and in-hospital mortality, and ICU and hospital stay. Restricted cubic spline (RCS), logistic regression, cox regression model, and receiver operating characteristic (ROC) curve were adopted to explore the relationship between CPB time and clinical endpoints.
resultsA total of 54,217 patients underwent cardiac surgery during the above period, of whom 210 patients developed ARDS after surgery and were finally included. The ICU mortality and in-hospital mortality were 21.0% and 41.9% in all ARDS patients after cardiac surgery respectively. Patients with long CPB time (CPB time ≥ 173 min) had longer length of ICU stay (P = 0.011), higher ICU (P < 0.001) mortality and in-hospital(P = 0.002) mortality compared with non-CPB patients (CPB = 0). For each ten minutes increment in CPB time, the hazards of a worse outcome increased by 13.3% for ICU mortality and 9.3% for in-hospital mortality after adjusting for potential factors. ROC curves showed CPB time presented more satisfactory power to predict mortality compared with APCHEII score. The optimal cut-off value of CPB time were 160.5 min for ICU mortality and in-hospital mortality.
conclusionsOur findings demonstrated the significant prognostic value of CPB time in patients with ARDS after cardiac surgery. Longer time of CPB was associated with poorer clinical outcomes, and could be served as an indicator to predict short-term mortality in patients with ARDS after cardiac surgery.
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