Trial reportBMC oral health2023
Effect of lactobacillus reuteri-derived probiotic nano-formulation on recurrent aphthous stomatitis: a double-blinded randomized clinical trial.
Trial report in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Prospective efficacy of a novel dual-pronged strategy combining the probiotic Lactobacillus casei and Microalga Chlorella vulgaris in preventing postmenopausal bone loss in ovariectomized rats.Archives of microbiology · 2026Article
- Article
- The Role of ProbioticsInternational journal of molecular sciences · 2026Review
- Prevalence, risk factors, and psychosocial impact of self-reported recurrent oral ulceration among Palestinian medical and dental students: a multicenter cross-sectional study.BMC oral health · 2026Article
- Clinical and Microbiological Changes Following Multi-Strain Probiotic Mouthrinse Use in Dental Students with Halitosis: A Prospective Single-Arm Study.Clinical, cosmetic and investigational dentistry · 2026Article
- Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy.Frontiers in oral health · 2025Review
- Applications of chitosan in oral health and diseases.Frontiers in oral health · 2025Review
- The Impact ofMicroorganisms · 2024Review
- Addressing mucosal ulcers during orthodontic treatment: An urgent call for preventive strategies.World journal of clinical cases · 2024Article
- Genetic Connectivity of Gut Microbiota and Oral Ulcers: A Mendelian Randomization Study.International dental journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe aimed to assess the therapeutic effects of a topical probiotic nano-formulation derived from Lactobacillus reuteri on treating recurrent aphthous stomatitis. MATERIALS AND
methods60 participants were randomly allocated into two groups (control and probiotic). Probiotic group administered topical probiotic nano-formulation three times a day for seven days. The control group administered a standard analgesic oral rinse. The size of ulcer(s) and pain severity were recorded on days 0, 3, 5, and 7 after intervention.
resultsBefore the intervention, the groups had no significant differences in terms of pain severity (P-value = 0.28) and lesion size (P-value = 0.24). Both groups exhibited significant reductions in pain severity and lesion size over the course of the intervention. After one week, the probiotic group had a notably larger lesion size reduction than the control group (P-value = 0.01). The probiotic group also showed a significantly greater reduction in pain severity than the control group (P-value = 0.04).
conclusionsApplying topical probiotic nano-formulation derived from Lactobacillus reuteri three times a day decreased lesion size and pain severity in RAS patients faster than the local analgesic oral rinse. CLINICAL RELEVANCE: Lactobacillus reuteri-derived probiotic nano-formulation might be a promising treatment option for RAS.
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