ArticleBMC infectious diseases2023
Clinical effects of bacteremia in sepsis patients with community-acquired pneumonia.
Article in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Clinical Characteristics, Empirical Antibiotic Appropriateness, and Outcomes of Gram-Positive Versus Gram-Negative Bacteremia in Emergency Department Patients with Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- Real-world clinical outcomes of macrophage activation-like syndrome and hyperferritinemia in sepsis: a retrospective database analysis.EClinicalMedicine · 2026Article
- Likelihood of Blood Culture Positivity Using SeptiCyte RAPID.Journal of clinical medicine · 2026Article
- A Retrospective Review of Antimicrobial Usage and Indications at End-of-Life for Oncology Patients in a Tertiary Cancer Center in Saudi Arabia.Saudi medical journal · 2026Article
- Bacterial prevalence and inflammatory changes in positive blood culture in community-acquired neonatal sepsis in Jordan.IJID regions · 2025Article
- Comparable Outcomes in Suspected Septic Shock: A Retrospective Study of Emergency Department Patients With and Without Bacteremia.The Journal of emergency medicine · 2025Observational
- The predictive performance of NEWS, MEWS, SOFA and SAPS II in outcomes of bacteremic and non-bacteremic sepsis.BMC infectious diseases · 2025Observational
- Likelihood of blood culture positivity using SeptiCyte RAPID.medRxiv : the preprint server for health sciences · 2025Article
- Prognostic value of multivariate logistic regression analysis and amyloid A lactate monitoring in patients with severe pneumonia-associated sepsis.BMC pulmonary medicine · 2025Article
- Presepsin, procalcitonin, interleukin-6, and high-sensitivity C-reactive protein for predicting bacterial DNAaemia among patients with sepsis.Journal of thoracic disease · 2025Article
- Article
- Steroids in severe community-acquired pneumonia.Breathe (Sheffield, England) · 2024Article
- Nucleic acid-based nanotherapeutics for treating sepsis and associated organ injuries.Theranostics · 2024Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundData regarding the clinical effects of bacteremia on severe community-acquired pneumonia (CAP) are limited. Thus, we investigated clinical characteristics and outcomes of severe CAP patients with bacteremia compared with those of subjects without bacteremia. In addition, we evaluated clinical factors associated with bacteremia at the time of sepsis awareness.
methodsWe enrolled sepsis patients diagnosed with CAP at emergency departments (EDs) from an ongoing nationwide multicenter observational registry, the Korean Sepsis Alliance, between September 2019 and December 2020. For evaluation of clinical factors associated with bacteremia, we divided eligible patients into bacteremia and non-bacteremia groups, and logistic regression analysis was performed using the clinical characteristics at the time of sepsis awareness.
resultDuring the study period, 1,510 (47.9%) sepsis patients were caused by CAP, and bacteremia was identified in 212 (14.0%) patients. Septic shock occurred more frequently in the bacteremia group than in the non-bacteremia group (27.4% vs. 14.8%; p < 0.001). In multivariable analysis, hematologic malignancies and septic shock were associated with an increased risk of bacteremia. However, chronic lung disease was associated with a decreased risk of bacteremia. Hospital mortality was significantly higher in the bacteremia group than in the non-bacteremia group (27.3% vs. 40.6%, p < 0.001). The most prevalent pathogen in blood culture was Klebsiella pneumoniae followed by Escherichia coli in gram-negative pathogens.
conclusionThe incidence of bacteremia in severe CAP was low at 14.0%, but the occurrence of bacteremia was associated with increased hospital mortality. In severe CAP, hematologic malignancies and septic shock were associated with an increased risk of bacteremia.
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