Evidence map›Paper›PMID 38114895›Full record

ArticleBMC nephrology2023

In vivo characterization of a podocyte-expressed short podocin isoform.

Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Linus ButtDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany.ORCID 0000-0002-2568-2998
David Unnersjö-JessDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany.ORCID 0000-0002-4162-0973
Dervla ReillyDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany.ORCID 0000-0001-5614-3113
Robert HahnfeldtDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany.ORCID 0000-0001-7997-3216
Markus M RinschenDepartment of Biomedicine and Aarhus Institute of Advanced Studies (AIAS), Aarhus University, Aarhus, Denmark.ORCID 0000-0002-9252-1342
Katarzyna BozekCenter for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, University Hospital Cologne, CECAD Building, Joseph-Stelzmann-Str. 62, 50931, Cologne, Germany.ORCID 0000-0002-0917-6876
Bernhard SchermerDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany.ORCID 0000-0002-5194-9000
Thomas BenzingDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany.ORCID 0000-0003-0512-1066
Martin HöhneDepartment II of Internal Medicine, University Hospital Cologne CECAD building Joseph-Stelzmann-Str. 62, Cologne, 50931, Germany. martin.hoehne@uk-koeln.de.ORCID 0000-0001-8698-5389
University of Cologne · DECologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEKarolinska University Hospital · SEUniversität Hamburg · DE

Funding

Bundesministerium für Bildung und Forschung 01ZX1917BBundesministerium für Bildung und Forschung BMBF 01-GM1901ECarlsbergfondet Young Researcher FellowshipDeutsche Forschungsgemeinschaft KFO 329, BR4917/3, INST 1856/71-1 FUGGElse Kröner-Fresenius-Stiftung,Germany Project No: 2019_KollegSE.04Eva Luise und Horst Köhler Stiftung Project No: 2019_KollegSE.04North Rhine-Westphalia return program 311-8.03.03.02-147635Novo Nordisk Fonden NNF19OC0056043
6 · The paper itself

Abstract

The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a second shorter isoform in the human kidney in addition to the well-studied canonical full-length protein. Distinct subcellular localization of the shorter isoform that lacks part of the conserved PHB domain suggested a physiological role. Here, we analyzed whether this protein can substitute for the canonical full-length protein. The short isoform of podocin is not found in other organisms except humans. We therefore analysed a mouse line expressing the equivalent podocin isoform (podocin

Indexed as

Nephrotic SyndromePodocytesAnimalsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceProtein IsoformsRNA, MessengerIntracellular Signaling Peptides and ProteinsMembrane ProteinsNPHS2 proteinProtein IsoformsRNA, MessengerPodocinPodocin isoformSlit-diaphragm morphologyTransgenic mouse

Identifiers

PMID38114895
PMCPMC10731740
OpenAlexW4389949502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.